TY - JOUR
T1 - MOFBOTS
T2 - Metal–Organic-Framework-Based Biomedical Microrobots
AU - Wang, Xiaopu
AU - Chen, Xiang Zhong
AU - Alcântara, Carlos C.J.
AU - Sevim, Semih
AU - Hoop, Marcus
AU - Terzopoulou, Anastasia
AU - de Marco, Carmela
AU - Hu, Chengzhi
AU - de Mello, Andrew J.
AU - Falcaro, Paolo
AU - Furukawa, Shuhei
AU - Nelson, Bradley J.
AU - Puigmartí-Luis, Josep
AU - Pané, Salvador
PY - 2019/7/5
Y1 - 2019/7/5
N2 - Motile metal−organic frameworks (MOFs) are potential candidates to serve as small-scale robotic platforms for applications in environmental remediation, targeted drug delivery, or nanosurgery. Here, magnetic helical microstructures coated with a kind of zinc-based MOF, zeolitic imidazole framework-8 (ZIF-8), with biocompatibility characteristics and pH-responsive features, are successfully fabricated. Moreover, it is shown that this highly integrated multifunctional device can swim along predesigned tracks under the control of weak rotational magnetic fields. The proposed systems can achieve single-cell targeting in a cell culture media and a controlled delivery of cargo payloads inside a complex microfluidic channel network. This new approach toward the fabrication of integrated multifunctional systems will open new avenues in soft microrobotics beyond current applications.
AB - Motile metal−organic frameworks (MOFs) are potential candidates to serve as small-scale robotic platforms for applications in environmental remediation, targeted drug delivery, or nanosurgery. Here, magnetic helical microstructures coated with a kind of zinc-based MOF, zeolitic imidazole framework-8 (ZIF-8), with biocompatibility characteristics and pH-responsive features, are successfully fabricated. Moreover, it is shown that this highly integrated multifunctional device can swim along predesigned tracks under the control of weak rotational magnetic fields. The proposed systems can achieve single-cell targeting in a cell culture media and a controlled delivery of cargo payloads inside a complex microfluidic channel network. This new approach toward the fabrication of integrated multifunctional systems will open new avenues in soft microrobotics beyond current applications.
KW - drug delivery
KW - metal–organic frameworks
KW - micromachines
KW - pH-responsive materials
KW - ZIF-8
UR - http://www.scopus.com/inward/record.url?scp=85065441583&partnerID=8YFLogxK
U2 - 10.1002/adma.201901592
DO - 10.1002/adma.201901592
M3 - Article
C2 - 31058366
AN - SCOPUS:85065441583
VL - 31
JO - Advanced Materials
JF - Advanced Materials
SN - 0935-9648
IS - 27
M1 - 1901592
ER -