Abstract
Mathematical models of individual ion
channels form the building blocks of complex in-silico
tools, enabling the investigation of biophysical mecha-
nisms and simulation of disease processes. We here
propose a first simplified hidden Markov Model (HMM)
for the voltage-gated potassium channel Kv1.1, taking
into account the channels’ specific activation and inac-
tivation characteristics close to physiological tempera-
ture. The modeling approach and simulation results
were compared with an existing Hodgkin Huxley
model based on the same experimental data. The
newly developed HMM shows a higher accuracy with
regard to the activation and inactivation behavior com-
pared to the Hodgkin Huxley approach.
channels form the building blocks of complex in-silico
tools, enabling the investigation of biophysical mecha-
nisms and simulation of disease processes. We here
propose a first simplified hidden Markov Model (HMM)
for the voltage-gated potassium channel Kv1.1, taking
into account the channels’ specific activation and inac-
tivation characteristics close to physiological tempera-
ture. The modeling approach and simulation results
were compared with an existing Hodgkin Huxley
model based on the same experimental data. The
newly developed HMM shows a higher accuracy with
regard to the activation and inactivation behavior com-
pared to the Hodgkin Huxley approach.
Original language | English |
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Title of host publication | Proceedings Annual Meeting of the Austrian Society for Biomedical Engineering 2021 |
Subtitle of host publication | ÖBGMT 2021 |
Editors | Gernot Müller-Putz, Christian Baumgartner |
Place of Publication | Graz |
Publisher | Verlag der Technischen Universität Graz |
Pages | 13-16 |
Number of pages | 4 |
ISBN (Print) | 978-3-85125-826-4 |
DOIs | |
Publication status | Published - 2021 |
Event | Annual Meeting of the Austrian Society of the Biomedical Engineering 2021: ÖGBMT 2021 - Graz University of Technology, Graz, Austria Duration: 30 Sept 2021 → 1 Oct 2021 https://oegbmt2021.tugraz.at/ |
Conference
Conference | Annual Meeting of the Austrian Society of the Biomedical Engineering 2021 |
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Abbreviated title | ÖGBMT 2021 |
Country/Territory | Austria |
City | Graz |
Period | 30/09/21 → 1/10/21 |
Internet address |
Fields of Expertise
- Human- & Biotechnology