Modeling external stimulation of excitable cells using a novel light-activated organic semiconductor technology

Sara Stoppacher*, Susanne Scheruebel, Muammer Üçal, Karin Kornmüller, Eric Głowacki, Rainer Schindl, Niroj Shrestha, Tony Schmidt, Christian Baumgartner, Theresa Margarethe Rienmüller

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference paper

Abstract

Optoelectronic neurostimulation is a promising, minimally invasive treatment modality for neuronal damage, in particular for patients with traumatic brain injury. In this work, a newly developed optoelectronic device, a so-called photocap, based on light-activated organic semiconductor structures with high spatial and temporal resolution is investigated. To prove and verify the feasibility of this new technology, a mathematical model was developed, simulating the electrical response of excitable cells to photocap stimulation. In the first step, a comprehensive technical review of the device concept was performed, building the basis for setting up the simulation model. The simulations demonstrate that photocaps may serve as a stimulation device, triggering action potentials in neural or cardiac cells. Our first results show that the model serves as a perfect tool for evaluating and further developing this new technology, showing high potential for introducing new and innovative therapy methods in the field of optoelectronic cell stimulation.
Original languageEnglish
Title of host publicationdHealth 2020 - Biomedical Informatics for Health and Care
Subtitle of host publicationProceedings of the 14th Health Informatics Meets Digital Health Conference
EditorsGunter Schreier, Dieter Hayn, Alphons Eggerth
Pages9-16
Number of pages8
Volume271
ISBN (Electronic)9781643680842
DOIs
Publication statusPublished - 23 Jun 2020
EventdHealth 2020 - Wien, Austria
Duration: 19 May 202020 May 2020

Publication series

NameStudies in Health Technology and Informatics
Volume271
ISSN (Print)0926-9630
ISSN (Electronic)1879-8365

Conference

ConferencedHealth 2020
CountryAustria
CityWien
Period19/05/2020/05/20

Keywords

  • optoelectronic stimulation
  • model simulation
  • excitable cells
  • traumatic brain injury
  • Traumatic brain injury
  • Optoelectronic stimulation
  • Excitable cells
  • Model simulation

ASJC Scopus subject areas

  • Health Information Management
  • Health Informatics
  • Biomedical Engineering

Fields of Expertise

  • Human- & Biotechnology

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