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Abstract
Optoelectronic neurostimulation is a promising, minimally invasive treatment modality for neuronal damage, in particular for patients with traumatic brain injury. In this work, a newly developed optoelectronic device, a so-called photocap, based on light-activated organic semiconductor structures with high spatial and temporal resolution is investigated. To prove and verify the feasibility of this new technology, a mathematical model was developed, simulating the electrical response of excitable cells to photocap stimulation. In the first step, a comprehensive technical review of the device concept was performed, building the basis for setting up the simulation model. The simulations demonstrate that photocaps may serve as a stimulation device, triggering action potentials in neural or cardiac cells. Our first results show that the model serves as a perfect tool for evaluating and further developing this new technology, showing high potential for introducing new and innovative therapy methods in the field of optoelectronic cell stimulation.
Original language | English |
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Title of host publication | dHealth 2020 - Biomedical Informatics for Health and Care |
Subtitle of host publication | Proceedings of the 14th Health Informatics Meets Digital Health Conference |
Editors | Gunter Schreier, Dieter Hayn, Alphons Eggerth |
Pages | 9-16 |
Number of pages | 8 |
Volume | 271 |
ISBN (Electronic) | 9781643680842 |
DOIs | |
Publication status | Published - 23 Jun 2020 |
Event | dHealth 2020 - Wien, Austria Duration: 19 May 2020 → 20 May 2020 |
Publication series
Name | Studies in Health Technology and Informatics |
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Volume | 271 |
ISSN (Print) | 0926-9630 |
ISSN (Electronic) | 1879-8365 |
Conference
Conference | dHealth 2020 |
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Country/Territory | Austria |
City | Wien |
Period | 19/05/20 → 20/05/20 |
Keywords
- optoelectronic stimulation
- model simulation
- excitable cells
- traumatic brain injury
- Traumatic brain injury
- Optoelectronic stimulation
- Excitable cells
- Model simulation
ASJC Scopus subject areas
- Health Information Management
- Health Informatics
- Biomedical Engineering
Fields of Expertise
- Human- & Biotechnology
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- 1 Active
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FWF - LOGOS-TBI - Light-controlled organic semiconductor implants for regeneration after TBI
Rienmüller, T. M., Langthaler, S., Stoppacher, S. & Ziesel, D.
1/05/19 → 30/04/24
Project: Research project