Modeling external stimulation of excitable cells using a novel light-activated organic semiconductor technology

Sara Stoppacher, Susanne Scheruebel, Muammer Üçal, Karin Kornmüller, Eric Głowacki, Rainer Schindl, Niroj Shrestha, Tony Schmidt, Christian Baumgartner, Theresa Margarethe Rienmüller

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

Abstract

Optoelectronic neurostimulation is a promising, minimally invasive treatment modality for neuronal damage, in particular for patients with traumatic brain injury. In this work, a newly developed optoelectronic device, a so-called photocap, based on light-activated organic semiconductor structures with high spatial and temporal resolution is investigated. To prove and verify the feasibility of this new technology, a mathematical model was developed, simulating the electrical response of excitable cells to photocap stimulation. In the first step, a comprehensive technical review of the device concept was performed, building the basis for setting up the simulation model. The simulations demonstrate that photocaps may serve as a stimulation device, triggering action potentials in neural or cardiac cells. Our first results show that the model serves as a perfect tool for evaluating and further developing this new technology, showing high potential for introducing new and innovative therapy methods in the field of optoelectronic cell stimulation.
Original languageEnglish
Title of host publication Stud Health Technol Inform
Subtitle of host publicationdHealth 2020 – Biomedical Informatics for Health and Care
Pages9-16
Number of pages8
Volume271
DOIs
Publication statusAccepted/In press - 2020
EventdHealth 2020 - Wien, Austria
Duration: 19 May 202020 May 2020

Conference

ConferencedHealth 2020
CountryAustria
CityWien
Period19/05/2020/05/20

Keywords

  • optoelectronic stimulation
  • model simulation
  • excitable cells
  • traumatic brain injury

Fields of Expertise

  • Human- & Biotechnology

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  • Cite this

    Stoppacher, S., Scheruebel, S., Üçal, M., Kornmüller, K., Głowacki, E., Schindl, R., ... Rienmüller, T. M. (Accepted/In press). Modeling external stimulation of excitable cells using a novel light-activated organic semiconductor technology. In Stud Health Technol Inform : dHealth 2020 – Biomedical Informatics for Health and Care (Vol. 271, pp. 9-16) https://doi.org/10.3233/SHTI200068