Modeling-based determination of physiological parameters of systemic VOCs by breath gas analysis: A pilot study

Karl Unterkofler; Julian King; Pawel Mochalski; Martin Jandacka; Helin Koc; Susanne Teschl; Anton Amann; Gerald Teschl

doi:10.1088/1752-7155/9/3/036002

Modeling-based determination of physiological parameters of systemic VOCs by breath gas analysis: A pilot study

Karl Unterkofler, Julian King, Pawel Mochalski, Martin Jandacka, Helin Koc, Susanne Teschl, Anton Amann, Gerald Teschl

Institute of Theoretical and Computational Physics (5150)

Research output: Contribution to journal › Article › peer-review

Abstract

In this paper we develop a simple two compartment model which extends the Farhi equation to the case when the inhaled concentration of a volatile organic compound (VOC) is not zero. The model connects the exhaled breath concentration of systemic VOCs with physiological parameters such as endogenous production rates and metabolic rates. Its validity is tested with data obtained for isoprene and inhaled deuterated isoprene-D5.

Original language	English
Article number	036002
Journal	Journal of Breath Research
Volume	9
Issue number	3
DOIs	https://doi.org/10.1088/1752-7155/9/3/036002
Publication status	Published - 6 May 2015

Keywords

breath gas analysis
Farhi equation
isoprene
metabolic rates
modeling
production rates
volatile organic compounds

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1088/1752-7155/9/3/036002

Cite this

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title = "Modeling-based determination of physiological parameters of systemic VOCs by breath gas analysis: A pilot study",

abstract = "In this paper we develop a simple two compartment model which extends the Farhi equation to the case when the inhaled concentration of a volatile organic compound (VOC) is not zero. The model connects the exhaled breath concentration of systemic VOCs with physiological parameters such as endogenous production rates and metabolic rates. Its validity is tested with data obtained for isoprene and inhaled deuterated isoprene-D5.",

keywords = "breath gas analysis, Farhi equation, isoprene, metabolic rates, modeling, production rates, volatile organic compounds",

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T2 - A pilot study

AU - Unterkofler, Karl

AU - King, Julian

AU - Mochalski, Pawel

AU - Jandacka, Martin

AU - Koc, Helin

AU - Teschl, Susanne

AU - Amann, Anton

AU - Teschl, Gerald

PY - 2015/5/6

Y1 - 2015/5/6

N2 - In this paper we develop a simple two compartment model which extends the Farhi equation to the case when the inhaled concentration of a volatile organic compound (VOC) is not zero. The model connects the exhaled breath concentration of systemic VOCs with physiological parameters such as endogenous production rates and metabolic rates. Its validity is tested with data obtained for isoprene and inhaled deuterated isoprene-D5.

AB - In this paper we develop a simple two compartment model which extends the Farhi equation to the case when the inhaled concentration of a volatile organic compound (VOC) is not zero. The model connects the exhaled breath concentration of systemic VOCs with physiological parameters such as endogenous production rates and metabolic rates. Its validity is tested with data obtained for isoprene and inhaled deuterated isoprene-D5.

KW - breath gas analysis

KW - Farhi equation

KW - isoprene

KW - metabolic rates

KW - modeling

KW - production rates

KW - volatile organic compounds

UR - http://www.scopus.com/inward/record.url?scp=84947968808&partnerID=8YFLogxK

U2 - 10.1088/1752-7155/9/3/036002

DO - 10.1088/1752-7155/9/3/036002

M3 - Article

SN - 1752-7155

VL - 9

JO - Journal of Breath Research

JF - Journal of Breath Research

IS - 3

M1 - 036002

ER -

Modeling-based determination of physiological parameters of systemic VOCs by breath gas analysis: A pilot study

Abstract

Keywords

ASJC Scopus subject areas

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