Method for immobilization of heparin on a polymeric material

Martina Modic; Metod Kolar; Karin Stana Kleinschek; Miran Mozetic; Ita Junkar; Alenka Vesel; Martina Modic; Metod Kolar; Miran Mozetic; Ita Junkar; Alenka Vesel

Method for immobilization of heparin on a polymeric material

Martina Modic (Inventor), Metod Kolar (Inventor), Karin Stana Kleinschek (Inventor), Miran Mozetic (Inventor), Ita Junkar (Inventor), Alenka Vesel (Inventor), Martina Modic (Inventor), Metod Kolar (Inventor), Miran Mozetic (Inventor), Ita Junkar (Inventor), Alenka Vesel (Inventor)

Research output: Patent

Abstract

A method for immobilization of heparin on polymeric material is disclosed, said method comprising selecting a substrate made from a polymeric material, pre-treating said substrate, mounting said substrate into a vacuum chamber, evacuating the vacuum chamber to pressure essentially below 100 Pa, preferably below 1 Pa, selecting a source of NH2 radicals, leaking the NH2 radicals from said source into said vacuum chamber during continuous pumping of said vacuum chamber, interacting said NH2 (NH 2 ) radicals with said substrate made from a polymeric material, evacuating said vacuum chamber, venting said vacuum chamber to atmospheric pressure, and covalent bonding of activated heparin on said substrate.

Translated title of the contribution	VERFAHREN ZUR IMMOBILISIERUNG EINES POLYMERMATERIALS
Original language	English
Patent number	EP2997984
IPC	A61L 33/ 00 A I
Priority date	19/09/14
Publication status	Published - 23 Mar 2016
Externally published	Yes

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Method for immobilization of heparin on a polymeric material. / Modic, Martina (Inventor); Kolar, Metod (Inventor); Stana Kleinschek, Karin (Inventor); Mozetic, Miran (Inventor); Junkar, Ita (Inventor); Vesel, Alenka (Inventor); Modic, Martina (Inventor); Kolar, Metod (Inventor); Mozetic, Miran (Inventor); Junkar, Ita (Inventor); Vesel, Alenka (Inventor).

IPC No.: A61L 33/ 00 A I. Patent No.: EP2997984. Mar 23, 2016.

Research output: Patent

Modic, Martina (Inventor) ; Kolar, Metod (Inventor) ; Stana Kleinschek, Karin (Inventor) ; Mozetic, Miran (Inventor) ; Junkar, Ita (Inventor) ; Vesel, Alenka (Inventor) ; Modic, Martina (Inventor) ; Kolar, Metod (Inventor) ; Mozetic, Miran (Inventor) ; Junkar, Ita (Inventor) ; Vesel, Alenka (Inventor). / Method for immobilization of heparin on a polymeric material. IPC No.: A61L 33/ 00 A I. Patent No.: EP2997984. Mar 23, 2016.

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abstract = "A method for immobilization of heparin on polymeric material is disclosed, said method comprising selecting a substrate made from a polymeric material, pre-treating said substrate, mounting said substrate into a vacuum chamber, evacuating the vacuum chamber to pressure essentially below 100 Pa, preferably below 1 Pa, selecting a source of NH2 radicals, leaking the NH2 radicals from said source into said vacuum chamber during continuous pumping of said vacuum chamber, interacting said NH2 (NH 2 ) radicals with said substrate made from a polymeric material, evacuating said vacuum chamber, venting said vacuum chamber to atmospheric pressure, and covalent bonding of activated heparin on said substrate.",

author = "Martina Modic and Metod Kolar and {Stana Kleinschek}, Karin and Miran Mozetic and Ita Junkar and Alenka Vesel and Martina Modic and Metod Kolar and Miran Mozetic and Ita Junkar and Alenka Vesel",

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T1 - Method for immobilization of heparin on a polymeric material

AU - Modic, Martina

AU - Kolar, Metod

AU - Stana Kleinschek, Karin

AU - Mozetic, Miran

AU - Junkar, Ita

AU - Vesel, Alenka

AU - Modic, Martina

AU - Kolar, Metod

AU - Mozetic, Miran

AU - Junkar, Ita

AU - Vesel, Alenka

PY - 2016/3/23

Y1 - 2016/3/23

N2 - A method for immobilization of heparin on polymeric material is disclosed, said method comprising selecting a substrate made from a polymeric material, pre-treating said substrate, mounting said substrate into a vacuum chamber, evacuating the vacuum chamber to pressure essentially below 100 Pa, preferably below 1 Pa, selecting a source of NH2 radicals, leaking the NH2 radicals from said source into said vacuum chamber during continuous pumping of said vacuum chamber, interacting said NH2 (NH 2 ) radicals with said substrate made from a polymeric material, evacuating said vacuum chamber, venting said vacuum chamber to atmospheric pressure, and covalent bonding of activated heparin on said substrate.

AB - A method for immobilization of heparin on polymeric material is disclosed, said method comprising selecting a substrate made from a polymeric material, pre-treating said substrate, mounting said substrate into a vacuum chamber, evacuating the vacuum chamber to pressure essentially below 100 Pa, preferably below 1 Pa, selecting a source of NH2 radicals, leaking the NH2 radicals from said source into said vacuum chamber during continuous pumping of said vacuum chamber, interacting said NH2 (NH 2 ) radicals with said substrate made from a polymeric material, evacuating said vacuum chamber, venting said vacuum chamber to atmospheric pressure, and covalent bonding of activated heparin on said substrate.

M3 - Patent

M1 - EP2997984

ER -