Metal-Organic Frameworks for Cell and Virus Biology: A Perspective

Raffaele Riccò, Weibin Liang, Shaobo Li, Jeremiah J Gassensmith, Frank Caruso, Christian Doonan, Paolo Falcaro

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Metal-organic frameworks (MOFs) are a class of coordination polymers, consisting of metal ions or clusters linked together by chemically mutable organic groups. In contrast to zeolites and porous carbons, MOFs are constructed from a building block strategy that enables molecular level control of pore size/shape and functionality. An area of growing interest in MOF chemistry is the synthesis of MOF-based composite materials. Recent studies have shown that MOFs can be combined with biomacromolecules to generate novel biocomposites. In such materials, the MOF acts as a porous matrix that can encapsulate enzymes, oligonucleotides, or even more complex structures that are capable of replication/reproduction (i.e., viruses, bacteria, and eukaryotic cells). The synthetic approach for the preparation of these materials has been termed "biomimetic mineralization", as it mimics natural biomineralization processes that afford protective shells around living systems. In this Perspective, we focus on the preparation of MOF biocomposites that are composed of complex biological moieties such as viruses and cells and canvass the potential applications of this encapsulation strategy to cell biology and biotechnology.

Original languageEnglish
Pages (from-to)13-23
Number of pages11
JournalACS Nano
Volume12
Issue number1
DOIs
Publication statusPublished - 23 Jan 2018

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viruses
Viruses
biology
Metals
metals
Cytology
Biomineralization
Zeolites
organic chemistry
preparation
biotechnology
oligonucleotides
Oligonucleotides
Level control
biomimetics
Biomimetics
metal clusters
Biotechnology
cells
coordination polymers

Keywords

  • Journal Article

Cite this

Metal-Organic Frameworks for Cell and Virus Biology : A Perspective. / Riccò, Raffaele; Liang, Weibin; Li, Shaobo; Gassensmith, Jeremiah J; Caruso, Frank; Doonan, Christian; Falcaro, Paolo.

In: ACS Nano, Vol. 12, No. 1, 23.01.2018, p. 13-23.

Research output: Contribution to journalArticleResearchpeer-review

Riccò, R, Liang, W, Li, S, Gassensmith, JJ, Caruso, F, Doonan, C & Falcaro, P 2018, 'Metal-Organic Frameworks for Cell and Virus Biology: A Perspective' ACS Nano, vol. 12, no. 1, pp. 13-23. https://doi.org/10.1021/acsnano.7b08056
Riccò R, Liang W, Li S, Gassensmith JJ, Caruso F, Doonan C et al. Metal-Organic Frameworks for Cell and Virus Biology: A Perspective. ACS Nano. 2018 Jan 23;12(1):13-23. https://doi.org/10.1021/acsnano.7b08056
Riccò, Raffaele ; Liang, Weibin ; Li, Shaobo ; Gassensmith, Jeremiah J ; Caruso, Frank ; Doonan, Christian ; Falcaro, Paolo. / Metal-Organic Frameworks for Cell and Virus Biology : A Perspective. In: ACS Nano. 2018 ; Vol. 12, No. 1. pp. 13-23.
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