Manipulating drug release from tridimensional porous substrates coated by initiated chemical vapor deposition

Laleh Ghasemi-Mobarakeh*, Oliver Werzer, Roman Keimel, Davood Kolahreez, Peter Hadley, Anna Maria Coclite

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

In the recent years, modern wound dressings have attracted much interest to accelerate wound healing processes with the topical delivery of drugs directly on wounds having a significant effect on wound rehabilitation. The objective of this study was to develop a model dressing that would not only provide wound protection from the environment but might also provide the possibility to keep it moist and deliver a drug for potential speeding the healing process. Poly(ethylene terephthalate), cotton fabrics, and polycaprolactone (PCL) nanofibers were used as different tridimensional porous substrates, loaded with a model drug, clotrimazole. The results show that the chemical structure and surface area to volume ratio of the pristine substrates affect the drug release profile. Coating of such substrates by hydrogels poly(2-hydroxyethyl methacrylate) (p-HEMA) and poly(methacrylic acid) (p-MAA) was successfully achieved by initiated chemical vapor deposition. This method was chosen because it is gentle and solventless and most important it can coat free areas within the three-dimensional structures. Scanning electron microscopy results revealed that p-HEMA and p-MAA conformally coated the fibers of the substrates. Moreover, drug release experiments showed that p-HEMA and p-MAA coatings provide barriers preventing sudden drug release. In conclusion, our results indicated the possibility of fabricating dressings containing a drug with tunable drug release profile depending on several parameters even though a strong porous structure exists.

Original languageEnglish
Article number47858
JournalJournal of applied polymer science
Volume136
Issue number33
DOIs
Publication statusPublished - 2019

Keywords

  • clotrimazole
  • drug release
  • initiated chemical vapor deposition (iCVD)
  • poly(2-hydroxyethyl methacrylate) (p-HEMA)
  • poly(methacrylic acid) (p-MAA)

ASJC Scopus subject areas

  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Polymers and Plastics
  • Materials Chemistry

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