Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells

H Furkan Alkan, Juliane G Bogner-Strauss

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Cancer cells rely on glutamine to fuel mitochondria, however it remains unclear whether this is needed for bioenergetic or biosynthetic pathways. Our study suggests that an essential function of mitochondrial glutamine metabolism is to provide aspartate to the cytosol where it can be used for nucleotide and protein synthesis.

Original languageEnglish
Pages (from-to)e1536843
JournalMolecular & Cellular Oncology
Volume6
Issue number5
DOIs
Publication statusPublished - 2019

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