Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells

H Furkan Alkan; Juliane G Bogner-Strauss

doi:10.1080/23723556.2018.1536843

Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells

H Furkan Alkan, Juliane G Bogner-Strauss

Institute of Biochemistry (6480)

Research output: Contribution to journal › Article › peer-review

Abstract

Cancer cells rely on glutamine to fuel mitochondria, however it remains unclear whether this is needed for bioenergetic or biosynthetic pathways. Our study suggests that an essential function of mitochondrial glutamine metabolism is to provide aspartate to the cytosol where it can be used for nucleotide and protein synthesis.

Original language	English
Pages (from-to)	e1536843
Journal	Molecular & Cellular Oncology
Volume	6
Issue number	5
DOIs	https://doi.org/10.1080/23723556.2018.1536843
Publication status	Published - 2019

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10.1080/23723556.2018.1536843

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title = "Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells",

abstract = "Cancer cells rely on glutamine to fuel mitochondria, however it remains unclear whether this is needed for bioenergetic or biosynthetic pathways. Our study suggests that an essential function of mitochondrial glutamine metabolism is to provide aspartate to the cytosol where it can be used for nucleotide and protein synthesis.",

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AB - Cancer cells rely on glutamine to fuel mitochondria, however it remains unclear whether this is needed for bioenergetic or biosynthetic pathways. Our study suggests that an essential function of mitochondrial glutamine metabolism is to provide aspartate to the cytosol where it can be used for nucleotide and protein synthesis.

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DO - 10.1080/23723556.2018.1536843

M3 - Article

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SN - 2372-3556

VL - 6

SP - e1536843

JO - Molecular & Cellular Oncology

JF - Molecular & Cellular Oncology

IS - 5

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Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells

Abstract

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