Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells

H Furkan Alkan, Juliane G Bogner-Strauss

Research output: Contribution to journalArticle


Cancer cells rely on glutamine to fuel mitochondria, however it remains unclear whether this is needed for bioenergetic or biosynthetic pathways. Our study suggests that an essential function of mitochondrial glutamine metabolism is to provide aspartate to the cytosol where it can be used for nucleotide and protein synthesis.

Original languageEnglish
Pages (from-to)e1536843
JournalMolecular & Cellular Oncology
Issue number5
Publication statusPublished - 2019

Cite this