(R)-Selective amination

Martin Schurmann (Inventor), Wijnand Peter Helena Peeters (Inventor), Natascha Hubertina Johannes Smeets (Inventor), Helmut Schwab (Inventor), Kerstin Steiner (Inventor), Kateryna Fesko (Inventor), Gernot Strohmeier (Inventor)

Research output: Patent

Abstract

The present invention relates to a method for the enzymic synthesis of enantiomerically enriched (R)-amines of general formula [1][c],from the corresponding ketones of general formula [1][a], by using novel transaminases. These novel transaminases are selected from two different groups: either from a group of some 20 proteins with sequences as specified herein, or from a group of proteins having transaminase activity and isolated from a microorganism selected from the group of organisms consisting of Rahnella aquatilis, Ochrobactrum anthropi, Ochrobactrum tritici, Sinorhizobium morelense, Curtobacterium pusilllum, Paecilomyces lilacinus, Microbacterium ginsengisoli, Microbacterium trichothecenolyticum, Pseudomonas citronellolis, Yersinia kristensenii, Achromobacter spanius, Achromobacter insolitus, Mycobacterium fortuitum, Mycobacterium frederiksbergense, Mycobacterium sacrum, Mycobacterium fluoranthenivorans, Burkholderia sp., Burkholderia tropica, Cosmospora episphaeria, and Fusarium oxysporum.
Original languageEnglish
Patent numberWO2012007548
IPCC12N1/14; C12N1/20; C12N15/54; C12N9/10; C12P13/00
Priority date14/07/10
Publication statusPublished - 19 Jan 2012

Keywords

  • Transaminase
  • Transamination

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  • Cite this

    Schurmann, M., Peeters, W. P. H., Smeets, N. H. J., Schwab, H., Steiner, K., Fesko, K., & Strohmeier, G. (2012). IPC No. C12N1/14; C12N1/20; C12N15/54; C12N9/10; C12P13/00. (R)-Selective amination. (Patent No. WO2012007548).