(R)-Selective amination

Martin Schurmann; Wijnand Peter Helena Peeters; Natascha Hubertina Johannes Smeets; Helmut Schwab; Kerstin Steiner; Kateryna Fesko; Gernot Strohmeier

(R)-Selective amination

Martin Schurmann (Inventor), Wijnand Peter Helena Peeters (Inventor), Natascha Hubertina Johannes Smeets (Inventor), Helmut Schwab (Inventor), Kerstin Steiner (Inventor), Kateryna Fesko (Inventor), Gernot Strohmeier (Inventor)

Research output: Patent

Abstract

The present invention relates to a method for the enzymic synthesis of enantiomerically enriched (R)-amines of general formula [1][c],from the corresponding ketones of general formula [1][a], by using novel transaminases. These novel transaminases are selected from two different groups: either from a group of some 20 proteins with sequences as specified herein, or from a group of proteins having transaminase activity and isolated from a microorganism selected from the group of organisms consisting of Rahnella aquatilis, Ochrobactrum anthropi, Ochrobactrum tritici, Sinorhizobium morelense, Curtobacterium pusilllum, Paecilomyces lilacinus, Microbacterium ginsengisoli, Microbacterium trichothecenolyticum, Pseudomonas citronellolis, Yersinia kristensenii, Achromobacter spanius, Achromobacter insolitus, Mycobacterium fortuitum, Mycobacterium frederiksbergense, Mycobacterium sacrum, Mycobacterium fluoranthenivorans, Burkholderia sp., Burkholderia tropica, Cosmospora episphaeria, and Fusarium oxysporum.

Original language	English
Patent number	WO2012007548
IPC	C12N1/14; C12N1/20; C12N15/54; C12N9/10; C12P13/00
Priority date	14/07/10
Publication status	Published - 19 Jan 2012

Keywords

Transaminase
Transamination

Cite this

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title = "(R)-Selective amination",

abstract = "The present invention relates to a method for the enzymic synthesis of enantiomerically enriched (R)-amines of general formula [1][c],from the corresponding ketones of general formula [1][a], by using novel transaminases. These novel transaminases are selected from two different groups: either from a group of some 20 proteins with sequences as specified herein, or from a group of proteins having transaminase activity and isolated from a microorganism selected from the group of organisms consisting of Rahnella aquatilis, Ochrobactrum anthropi, Ochrobactrum tritici, Sinorhizobium morelense, Curtobacterium pusilllum, Paecilomyces lilacinus, Microbacterium ginsengisoli, Microbacterium trichothecenolyticum, Pseudomonas citronellolis, Yersinia kristensenii, Achromobacter spanius, Achromobacter insolitus, Mycobacterium fortuitum, Mycobacterium frederiksbergense, Mycobacterium sacrum, Mycobacterium fluoranthenivorans, Burkholderia sp., Burkholderia tropica, Cosmospora episphaeria, and Fusarium oxysporum.",

keywords = "Transaminase, Transamination",

author = "Martin Schurmann and Peeters, {Wijnand Peter Helena} and Smeets, {Natascha Hubertina Johannes} and Helmut Schwab and Kerstin Steiner and Kateryna Fesko and Gernot Strohmeier",

year = "2012",

month = jan,

day = "19",

language = "English",

type = "Patent",

note = "WO2012007548; C12N1/14; C12N1/20; C12N15/54; C12N9/10; C12P13/00",

}

TY - PAT

T1 - (R)-Selective amination

AU - Schurmann, Martin

AU - Peeters, Wijnand Peter Helena

AU - Smeets, Natascha Hubertina Johannes

AU - Schwab, Helmut

AU - Steiner, Kerstin

AU - Fesko, Kateryna

AU - Strohmeier, Gernot

PY - 2012/1/19

Y1 - 2012/1/19

N2 - The present invention relates to a method for the enzymic synthesis of enantiomerically enriched (R)-amines of general formula [1][c],from the corresponding ketones of general formula [1][a], by using novel transaminases. These novel transaminases are selected from two different groups: either from a group of some 20 proteins with sequences as specified herein, or from a group of proteins having transaminase activity and isolated from a microorganism selected from the group of organisms consisting of Rahnella aquatilis, Ochrobactrum anthropi, Ochrobactrum tritici, Sinorhizobium morelense, Curtobacterium pusilllum, Paecilomyces lilacinus, Microbacterium ginsengisoli, Microbacterium trichothecenolyticum, Pseudomonas citronellolis, Yersinia kristensenii, Achromobacter spanius, Achromobacter insolitus, Mycobacterium fortuitum, Mycobacterium frederiksbergense, Mycobacterium sacrum, Mycobacterium fluoranthenivorans, Burkholderia sp., Burkholderia tropica, Cosmospora episphaeria, and Fusarium oxysporum.

AB - The present invention relates to a method for the enzymic synthesis of enantiomerically enriched (R)-amines of general formula [1][c],from the corresponding ketones of general formula [1][a], by using novel transaminases. These novel transaminases are selected from two different groups: either from a group of some 20 proteins with sequences as specified herein, or from a group of proteins having transaminase activity and isolated from a microorganism selected from the group of organisms consisting of Rahnella aquatilis, Ochrobactrum anthropi, Ochrobactrum tritici, Sinorhizobium morelense, Curtobacterium pusilllum, Paecilomyces lilacinus, Microbacterium ginsengisoli, Microbacterium trichothecenolyticum, Pseudomonas citronellolis, Yersinia kristensenii, Achromobacter spanius, Achromobacter insolitus, Mycobacterium fortuitum, Mycobacterium frederiksbergense, Mycobacterium sacrum, Mycobacterium fluoranthenivorans, Burkholderia sp., Burkholderia tropica, Cosmospora episphaeria, and Fusarium oxysporum.

KW - Transaminase

KW - Transamination

M3 - Patent

M1 - WO2012007548

ER -

(R)-Selective amination

Abstract

Keywords

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