(R)-Selective amination

Martin Schurmann (Inventor), Wijnand Peter Helena Peeters (Inventor), Natascha Hubertina Johannes Smeets (Inventor), Helmut Schwab (Inventor), Kerstin Steiner (Inventor), Kateryna Fesko (Inventor), Gernot Strohmeier (Inventor)

Research output: PatentResearch

Abstract

The present invention relates to a method for the enzymic synthesis of enantiomerically enriched (R)-amines of general formula [1][c],from the corresponding ketones of general formula [1][a], by using novel transaminases. These novel transaminases are selected from two different groups: either from a group of some 20 proteins with sequences as specified herein, or from a group of proteins having transaminase activity and isolated from a microorganism selected from the group of organisms consisting of Rahnella aquatilis, Ochrobactrum anthropi, Ochrobactrum tritici, Sinorhizobium morelense, Curtobacterium pusilllum, Paecilomyces lilacinus, Microbacterium ginsengisoli, Microbacterium trichothecenolyticum, Pseudomonas citronellolis, Yersinia kristensenii, Achromobacter spanius, Achromobacter insolitus, Mycobacterium fortuitum, Mycobacterium frederiksbergense, Mycobacterium sacrum, Mycobacterium fluoranthenivorans, Burkholderia sp., Burkholderia tropica, Cosmospora episphaeria, and Fusarium oxysporum.
Original languageEnglish
Patent numberWO2012007548
IPCC12N1/14; C12N1/20; C12N15/54; C12N9/10; C12P13/00
Priority date14/07/10
Publication statusPublished - 19 Jan 2012

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Amination
Transaminases
Patents and inventions
Ketones
Microorganisms
Amines
Proteins

Keywords

  • Transaminase
  • Transamination

Cite this

Schurmann, M., Peeters, W. P. H., Smeets, N. H. J., Schwab, H., Steiner, K., Fesko, K., & Strohmeier, G. (2012). IPC No. C12N1/14; C12N1/20; C12N15/54; C12N9/10; C12P13/00. (R)-Selective amination. (Patent No. WO2012007548).

(R)-Selective amination. / Schurmann, Martin (Inventor); Peeters, Wijnand Peter Helena (Inventor); Smeets, Natascha Hubertina Johannes (Inventor); Schwab, Helmut (Inventor); Steiner, Kerstin (Inventor); Fesko, Kateryna (Inventor); Strohmeier, Gernot (Inventor).

IPC No.: C12N1/14; C12N1/20; C12N15/54; C12N9/10; C12P13/00. Patent No.: WO2012007548.

Research output: PatentResearch

Schurmann, M, Peeters, WPH, Smeets, NHJ, Schwab, H, Steiner, K, Fesko, K & Strohmeier, G 2012, (R)-Selective amination, Patent No. WO2012007548, IPC No. C12N1/14; C12N1/20; C12N15/54; C12N9/10; C12P13/00.
Schurmann M, Peeters WPH, Smeets NHJ, Schwab H, Steiner K, Fesko K et al, inventors. (R)-Selective amination. C12N1/14; C12N1/20; C12N15/54; C12N9/10; C12P13/00. 2012 Jan 19.
Schurmann, Martin (Inventor) ; Peeters, Wijnand Peter Helena (Inventor) ; Smeets, Natascha Hubertina Johannes (Inventor) ; Schwab, Helmut (Inventor) ; Steiner, Kerstin (Inventor) ; Fesko, Kateryna (Inventor) ; Strohmeier, Gernot (Inventor). / (R)-Selective amination. IPC No.: C12N1/14; C12N1/20; C12N15/54; C12N9/10; C12P13/00. Patent No.: WO2012007548.
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abstract = "The present invention relates to a method for the enzymic synthesis of enantiomerically enriched (R)-amines of general formula [1][c],from the corresponding ketones of general formula [1][a], by using novel transaminases. These novel transaminases are selected from two different groups: either from a group of some 20 proteins with sequences as specified herein, or from a group of proteins having transaminase activity and isolated from a microorganism selected from the group of organisms consisting of Rahnella aquatilis, Ochrobactrum anthropi, Ochrobactrum tritici, Sinorhizobium morelense, Curtobacterium pusilllum, Paecilomyces lilacinus, Microbacterium ginsengisoli, Microbacterium trichothecenolyticum, Pseudomonas citronellolis, Yersinia kristensenii, Achromobacter spanius, Achromobacter insolitus, Mycobacterium fortuitum, Mycobacterium frederiksbergense, Mycobacterium sacrum, Mycobacterium fluoranthenivorans, Burkholderia sp., Burkholderia tropica, Cosmospora episphaeria, and Fusarium oxysporum.",
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AU - Fesko, Kateryna

AU - Strohmeier, Gernot

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N2 - The present invention relates to a method for the enzymic synthesis of enantiomerically enriched (R)-amines of general formula [1][c],from the corresponding ketones of general formula [1][a], by using novel transaminases. These novel transaminases are selected from two different groups: either from a group of some 20 proteins with sequences as specified herein, or from a group of proteins having transaminase activity and isolated from a microorganism selected from the group of organisms consisting of Rahnella aquatilis, Ochrobactrum anthropi, Ochrobactrum tritici, Sinorhizobium morelense, Curtobacterium pusilllum, Paecilomyces lilacinus, Microbacterium ginsengisoli, Microbacterium trichothecenolyticum, Pseudomonas citronellolis, Yersinia kristensenii, Achromobacter spanius, Achromobacter insolitus, Mycobacterium fortuitum, Mycobacterium frederiksbergense, Mycobacterium sacrum, Mycobacterium fluoranthenivorans, Burkholderia sp., Burkholderia tropica, Cosmospora episphaeria, and Fusarium oxysporum.

AB - The present invention relates to a method for the enzymic synthesis of enantiomerically enriched (R)-amines of general formula [1][c],from the corresponding ketones of general formula [1][a], by using novel transaminases. These novel transaminases are selected from two different groups: either from a group of some 20 proteins with sequences as specified herein, or from a group of proteins having transaminase activity and isolated from a microorganism selected from the group of organisms consisting of Rahnella aquatilis, Ochrobactrum anthropi, Ochrobactrum tritici, Sinorhizobium morelense, Curtobacterium pusilllum, Paecilomyces lilacinus, Microbacterium ginsengisoli, Microbacterium trichothecenolyticum, Pseudomonas citronellolis, Yersinia kristensenii, Achromobacter spanius, Achromobacter insolitus, Mycobacterium fortuitum, Mycobacterium frederiksbergense, Mycobacterium sacrum, Mycobacterium fluoranthenivorans, Burkholderia sp., Burkholderia tropica, Cosmospora episphaeria, and Fusarium oxysporum.

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KW - Transamination

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