In-vitro measurement of iron concentration in human hepatic tissue by magnetic induction methods

R. Casañas, H. Scharfetter, A. Altes, A. Remacha, P. Sarda, J. Sierra, J. Rosell

Research output: Contribution to journalConference articleResearchpeer-review

Abstract

This article studies the feasibility of a magnetic induction (MI) based system to measure the concentration of paramagnetic material in biological tissues. Our final objective is the measurement of hepatic iron overload with a non-invasive method. We have used an analytical expression, for a disc of conducting paramagnetic or diagmagnetic material, to estimate the response of the system. Experimental data were acquired with a custom measurement system using an excitation coil and a planar gradiometer as receiver. The output of the system for different concentration of FeCl3 solutions has been used to calibrate the system. Ten in-vitro measurements of liver samples, with a volume around 50 cm3, have been made. Measurements were compared against a biochemical iron estimation procedure and histological studies with hematoxilin-eosin and Perls Prussian blue staining. A significant agreement is observed (R=0.92, P<0.001) between biochemical and MI results. The systems and procedures used have to be adapted now for in-vivo non-invasive measurements.

Original languageEnglish
Pages (from-to)2971-2974
Number of pages4
JournalAnnual Reports of the Research Reactor Institute, Kyoto University
Volume3
Publication statusPublished - 1 Dec 2001
Externally publishedYes
Event23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Istanbul, Turkey
Duration: 25 Oct 200128 Oct 2001

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Electromagnetic induction
Tissue
Iron
Paramagnetic materials
Liver

Keywords

  • Hemochromatosis
  • Hepatic iron
  • Magnetic induction

ASJC Scopus subject areas

  • Energy Engineering and Power Technology
  • Mechanical Engineering

Cite this

In-vitro measurement of iron concentration in human hepatic tissue by magnetic induction methods. / Casañas, R.; Scharfetter, H.; Altes, A.; Remacha, A.; Sarda, P.; Sierra, J.; Rosell, J.

In: Annual Reports of the Research Reactor Institute, Kyoto University, Vol. 3, 01.12.2001, p. 2971-2974.

Research output: Contribution to journalConference articleResearchpeer-review

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AU - Altes, A.

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AU - Sarda, P.

AU - Sierra, J.

AU - Rosell, J.

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N2 - This article studies the feasibility of a magnetic induction (MI) based system to measure the concentration of paramagnetic material in biological tissues. Our final objective is the measurement of hepatic iron overload with a non-invasive method. We have used an analytical expression, for a disc of conducting paramagnetic or diagmagnetic material, to estimate the response of the system. Experimental data were acquired with a custom measurement system using an excitation coil and a planar gradiometer as receiver. The output of the system for different concentration of FeCl3 solutions has been used to calibrate the system. Ten in-vitro measurements of liver samples, with a volume around 50 cm3, have been made. Measurements were compared against a biochemical iron estimation procedure and histological studies with hematoxilin-eosin and Perls Prussian blue staining. A significant agreement is observed (R=0.92, P<0.001) between biochemical and MI results. The systems and procedures used have to be adapted now for in-vivo non-invasive measurements.

AB - This article studies the feasibility of a magnetic induction (MI) based system to measure the concentration of paramagnetic material in biological tissues. Our final objective is the measurement of hepatic iron overload with a non-invasive method. We have used an analytical expression, for a disc of conducting paramagnetic or diagmagnetic material, to estimate the response of the system. Experimental data were acquired with a custom measurement system using an excitation coil and a planar gradiometer as receiver. The output of the system for different concentration of FeCl3 solutions has been used to calibrate the system. Ten in-vitro measurements of liver samples, with a volume around 50 cm3, have been made. Measurements were compared against a biochemical iron estimation procedure and histological studies with hematoxilin-eosin and Perls Prussian blue staining. A significant agreement is observed (R=0.92, P<0.001) between biochemical and MI results. The systems and procedures used have to be adapted now for in-vivo non-invasive measurements.

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