Abstract
This article studies the feasibility of a magnetic induction (MI) based system to measure the concentration of paramagnetic material in biological tissues. Our final objective is the measurement of hepatic iron overload with a non-invasive method. We have used an analytical expression, for a disc of conducting paramagnetic or diagmagnetic material, to estimate the response of the system. Experimental data were acquired with a custom measurement system using an excitation coil and a planar gradiometer as receiver. The output of the system for different concentration of FeCl3 solutions has been used to calibrate the system. Ten in-vitro measurements of liver samples, with a volume around 50 cm3, have been made. Measurements were compared against a biochemical iron estimation procedure and histological studies with hematoxilin-eosin and Perls Prussian blue staining. A significant agreement is observed (R=0.92, P<0.001) between biochemical and MI results. The systems and procedures used have to be adapted now for in-vivo non-invasive measurements.
Original language | English |
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Pages (from-to) | 2971-2974 |
Number of pages | 4 |
Journal | Annual Reports of the Research Reactor Institute, Kyoto University |
Volume | 3 |
Publication status | Published - 1 Dec 2001 |
Externally published | Yes |
Event | 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Istanbul, Turkey Duration: 25 Oct 2001 → 28 Oct 2001 |
Keywords
- Hemochromatosis
- Hepatic iron
- Magnetic induction
ASJC Scopus subject areas
- Energy Engineering and Power Technology
- Mechanical Engineering