In-line measurement of residence time distribution in melt extrusion via video analysis

P. R. Wahl, G. Hörl, D. Kaiser, S. Sacher, Ch Rupp, G. Shlieout, J. Breitenbach, G. Koscher, J. G. Khinast

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Residence time distribution (RTD) is an important factor in melt extrusion as it strongly influences the product quality. It can cause degradation of the active pharmaceutical ingredient (API), which can be reduced by shorter mean residence times, and the content uniformity, which can be improved by broadening the RTD caused by axial mixing. In our study, we developed an inline video analysis that to date has mainly been applied offline. For extrusion, hydrophilic polymer and a surfactant were used as a molten matrix, in which an API was embedded. The video analysis consisted of four steps: (1) segmentation of the image to mask the strands, (2) calculation of average color values for the segmented pixels of each frame, (3) fitting of the obtained color curve with an analytical solution, and (4) calculating several RTD measures (e.g., the minimal and mean RT) for better comparison of the results. The RTD measures were responses in the design of experiments (DoE), which included the process parameters screw design, screw speed, and throughput. This analysis clearly showed that screw design had the strongest effect on the RTD measures. The results suggest that video analysis is a suitable tool for inline RTD measurements. POLYM. ENG. SCI., 58:170–179, 2018.

Original languageEnglish
Pages (from-to)170-179
Number of pages10
JournalPolymer Engineering and Science
Volume58
Issue number2
DOIs
Publication statusPublished - 1 Feb 2018

Fingerprint

Residence time distribution
Extrusion
Drug products
Color
Surface-Active Agents
Pharmaceutical Preparations
Design of experiments
Molten materials
Masks
Polymers
Surface active agents
Pixels
Throughput
Degradation

ASJC Scopus subject areas

  • Chemistry(all)
  • Polymers and Plastics
  • Materials Chemistry

Cite this

In-line measurement of residence time distribution in melt extrusion via video analysis. / Wahl, P. R.; Hörl, G.; Kaiser, D.; Sacher, S.; Rupp, Ch; Shlieout, G.; Breitenbach, J.; Koscher, G.; Khinast, J. G.

In: Polymer Engineering and Science, Vol. 58, No. 2, 01.02.2018, p. 170-179.

Research output: Contribution to journalArticleResearchpeer-review

@article{3b1f0aaec9ad4c67b6d2c989ea1aae9d,
title = "In-line measurement of residence time distribution in melt extrusion via video analysis",
abstract = "Residence time distribution (RTD) is an important factor in melt extrusion as it strongly influences the product quality. It can cause degradation of the active pharmaceutical ingredient (API), which can be reduced by shorter mean residence times, and the content uniformity, which can be improved by broadening the RTD caused by axial mixing. In our study, we developed an inline video analysis that to date has mainly been applied offline. For extrusion, hydrophilic polymer and a surfactant were used as a molten matrix, in which an API was embedded. The video analysis consisted of four steps: (1) segmentation of the image to mask the strands, (2) calculation of average color values for the segmented pixels of each frame, (3) fitting of the obtained color curve with an analytical solution, and (4) calculating several RTD measures (e.g., the minimal and mean RT) for better comparison of the results. The RTD measures were responses in the design of experiments (DoE), which included the process parameters screw design, screw speed, and throughput. This analysis clearly showed that screw design had the strongest effect on the RTD measures. The results suggest that video analysis is a suitable tool for inline RTD measurements. POLYM. ENG. SCI., 58:170–179, 2018.",
author = "Wahl, {P. R.} and G. H{\"o}rl and D. Kaiser and S. Sacher and Ch Rupp and G. Shlieout and J. Breitenbach and G. Koscher and Khinast, {J. G.}",
year = "2018",
month = "2",
day = "1",
doi = "10.1002/pen.24544",
language = "English",
volume = "58",
pages = "170--179",
journal = "Polymer engineering & science",
issn = "0032-3888",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - In-line measurement of residence time distribution in melt extrusion via video analysis

AU - Wahl, P. R.

AU - Hörl, G.

AU - Kaiser, D.

AU - Sacher, S.

AU - Rupp, Ch

AU - Shlieout, G.

AU - Breitenbach, J.

AU - Koscher, G.

AU - Khinast, J. G.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Residence time distribution (RTD) is an important factor in melt extrusion as it strongly influences the product quality. It can cause degradation of the active pharmaceutical ingredient (API), which can be reduced by shorter mean residence times, and the content uniformity, which can be improved by broadening the RTD caused by axial mixing. In our study, we developed an inline video analysis that to date has mainly been applied offline. For extrusion, hydrophilic polymer and a surfactant were used as a molten matrix, in which an API was embedded. The video analysis consisted of four steps: (1) segmentation of the image to mask the strands, (2) calculation of average color values for the segmented pixels of each frame, (3) fitting of the obtained color curve with an analytical solution, and (4) calculating several RTD measures (e.g., the minimal and mean RT) for better comparison of the results. The RTD measures were responses in the design of experiments (DoE), which included the process parameters screw design, screw speed, and throughput. This analysis clearly showed that screw design had the strongest effect on the RTD measures. The results suggest that video analysis is a suitable tool for inline RTD measurements. POLYM. ENG. SCI., 58:170–179, 2018.

AB - Residence time distribution (RTD) is an important factor in melt extrusion as it strongly influences the product quality. It can cause degradation of the active pharmaceutical ingredient (API), which can be reduced by shorter mean residence times, and the content uniformity, which can be improved by broadening the RTD caused by axial mixing. In our study, we developed an inline video analysis that to date has mainly been applied offline. For extrusion, hydrophilic polymer and a surfactant were used as a molten matrix, in which an API was embedded. The video analysis consisted of four steps: (1) segmentation of the image to mask the strands, (2) calculation of average color values for the segmented pixels of each frame, (3) fitting of the obtained color curve with an analytical solution, and (4) calculating several RTD measures (e.g., the minimal and mean RT) for better comparison of the results. The RTD measures were responses in the design of experiments (DoE), which included the process parameters screw design, screw speed, and throughput. This analysis clearly showed that screw design had the strongest effect on the RTD measures. The results suggest that video analysis is a suitable tool for inline RTD measurements. POLYM. ENG. SCI., 58:170–179, 2018.

UR - http://www.scopus.com/inward/record.url?scp=85015161204&partnerID=8YFLogxK

U2 - 10.1002/pen.24544

DO - 10.1002/pen.24544

M3 - Article

VL - 58

SP - 170

EP - 179

JO - Polymer engineering & science

JF - Polymer engineering & science

SN - 0032-3888

IS - 2

ER -