Iminosugars and relatives as antiviral and potential anti-infective agents

Peter Greimel; Josef Spreitz; Arnold Stütz; Tanja Wrodnigg

doi:10.2174/1568026033452456

Iminosugars and relatives as antiviral and potential anti-infective agents

Peter Greimel, Josef Spreitz, Arnold Stütz, Tanja Wrodnigg

Institute of Organic Chemistry (6410)

Research output: Contribution to journal › Review article › peer-review

Abstract

Iminosugars have emerged in the literature during mid-1960's as synthetic compounds. Around the same time, the first examples were found in Nature and their interesting enzyme inhibitory properties were recognised. Due to their powerful interference with glycohydrolases (glycosidases) as well as glycosyltransferases, quite a few representatives exhibit notable biological activities. These range from anti-diabetic, insect antifeedant, nematicidal, plant growth regulating to immunomodulating, anti-cancer as well as - in selected cases - anti-infective properties. The latter will be the focus of the following survey.

Original language	English
Pages (from-to)	513-23
Number of pages	11
Journal	Current Topics in Medicinal Chemistry
Volume	3
Issue number	5
DOIs	https://doi.org/10.2174/1568026033452456
Publication status	Published - 2003

Keywords

Animals
Anti-Infective Agents/chemistry
Antiprotozoal Agents/chemical synthesis
Antiviral Agents/chemistry
Enzyme Inhibitors/chemistry
Humans
Monosaccharides/chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.2174/1568026033452456

Cite this

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title = "Iminosugars and relatives as antiviral and potential anti-infective agents",

abstract = "Iminosugars have emerged in the literature during mid-1960's as synthetic compounds. Around the same time, the first examples were found in Nature and their interesting enzyme inhibitory properties were recognised. Due to their powerful interference with glycohydrolases (glycosidases) as well as glycosyltransferases, quite a few representatives exhibit notable biological activities. These range from anti-diabetic, insect antifeedant, nematicidal, plant growth regulating to immunomodulating, anti-cancer as well as - in selected cases - anti-infective properties. The latter will be the focus of the following survey.",

keywords = "Animals, Anti-Infective Agents/chemistry, Antiprotozoal Agents/chemical synthesis, Antiviral Agents/chemistry, Enzyme Inhibitors/chemistry, Humans, Monosaccharides/chemistry",

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T1 - Iminosugars and relatives as antiviral and potential anti-infective agents

AU - Greimel, Peter

AU - Spreitz, Josef

AU - Stütz, Arnold

AU - Wrodnigg, Tanja

PY - 2003

Y1 - 2003

N2 - Iminosugars have emerged in the literature during mid-1960's as synthetic compounds. Around the same time, the first examples were found in Nature and their interesting enzyme inhibitory properties were recognised. Due to their powerful interference with glycohydrolases (glycosidases) as well as glycosyltransferases, quite a few representatives exhibit notable biological activities. These range from anti-diabetic, insect antifeedant, nematicidal, plant growth regulating to immunomodulating, anti-cancer as well as - in selected cases - anti-infective properties. The latter will be the focus of the following survey.

AB - Iminosugars have emerged in the literature during mid-1960's as synthetic compounds. Around the same time, the first examples were found in Nature and their interesting enzyme inhibitory properties were recognised. Due to their powerful interference with glycohydrolases (glycosidases) as well as glycosyltransferases, quite a few representatives exhibit notable biological activities. These range from anti-diabetic, insect antifeedant, nematicidal, plant growth regulating to immunomodulating, anti-cancer as well as - in selected cases - anti-infective properties. The latter will be the focus of the following survey.

KW - Animals

KW - Anti-Infective Agents/chemistry

KW - Antiprotozoal Agents/chemical synthesis

KW - Antiviral Agents/chemistry

KW - Enzyme Inhibitors/chemistry

KW - Humans

KW - Monosaccharides/chemistry

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DO - 10.2174/1568026033452456

M3 - Review article

C2 - 12570863

SN - 1568-0266

VL - 3

SP - 513

EP - 523

JO - Current Topics in Medicinal Chemistry

JF - Current Topics in Medicinal Chemistry

IS - 5

ER -