Iminosugars and relatives as antiviral and potential anti-infective agents

Peter Greimel, Josef Spreitz, Arnold Stütz, Tanja Wrodnigg

Research output: Contribution to journalReview articlepeer-review

Abstract

Iminosugars have emerged in the literature during mid-1960's as synthetic compounds. Around the same time, the first examples were found in Nature and their interesting enzyme inhibitory properties were recognised. Due to their powerful interference with glycohydrolases (glycosidases) as well as glycosyltransferases, quite a few representatives exhibit notable biological activities. These range from anti-diabetic, insect antifeedant, nematicidal, plant growth regulating to immunomodulating, anti-cancer as well as - in selected cases - anti-infective properties. The latter will be the focus of the following survey.

Original languageEnglish
Pages (from-to)513-23
Number of pages11
JournalCurrent topics in medicinal chemistry
Volume3
Issue number5
DOIs
Publication statusPublished - 2003

Keywords

  • Animals
  • Anti-Infective Agents/chemistry
  • Antiprotozoal Agents/chemical synthesis
  • Antiviral Agents/chemistry
  • Enzyme Inhibitors/chemistry
  • Humans
  • Monosaccharides/chemistry

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