Image-Driven Constitutive Modelling of Myocardial Fibrosis

Vicky Y. Wang, Justyna Anna Niestrawska, Alexander J. Wilson, Gregory B. Sands, Alistair A. Young, Ian J. LeGrice, Martyn P. Nash

Research output: Contribution to journalArticlepeer-review


Myocardial fibrosis is a pathological process that occurs during heart failure (HF). It involves microstructural remodeling of normal myocardial tissue, and consequent changes in both cardiac geometry and function. The role of myocardial structural remodeling in the progression of HF remains poorly understood. We propose a constitutive modeling framework, informed by high-resolution images of cardiac tissue structure, to model the mechanical response of normal and fibrotic myocardium. This image-driven constitutive modeling approach allows us to better reproduce and understand the relationship between structural and functional remodeling of ventricular myocardium during HF.
Original languageEnglish
Pages (from-to)211-221
JournalInternational Journal for Computational Methods in Engineering Science and Mechanics
Issue number3
Publication statusPublished - 17 May 2016


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