High-Field Detection of Biomarkers with Fast Field-Cycling MRI: The Example of Zinc Sensing

Markus Bödenler, Kyangwi P. Malikidogo, Jean François Morfin, Christoph Stefan Aigner, Éva Tóth, Célia S. Bonnet*, Hermann Scharfetter

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Many smart magnetic resonance imaging (MRI) probes provide response to a biomarker based on modulation of their rotational correlation time. The magnitude of such MRI signal changes is highly dependent on the magnetic field and the response decreases dramatically at high fields (>2 T). To overcome the loss of efficiency of responsive probes at high field, with fast-field cycling magnetic resonance imaging (FFC-MRI) we exploit field-dependent information rather than the absolute difference in the relaxation rate measured in the absence and in the presence of the biomarker at a given imaging field. We report here the application of fast field-cycling techniques combined with the use of a molecular probe for the detection of Zn2+ to achieve 166 % MRI signal enhancement at 3 T, whereas the same agent provides no detectable response using conventional MRI. This approach can be generalized to any biomarker provided the detection is based on variation of the rotational motion of the probe.

Original languageEnglish
Pages (from-to)8236-8239
Number of pages4
JournalChemistry - a European Journal
Volume25
Issue number35
DOIs
Publication statusPublished - 21 Jun 2019

Keywords

  • contrast agents
  • fast field-cycling
  • high-field detection
  • magnetic resonance imaging
  • molecular imaging

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Organic Chemistry

Fields of Expertise

  • Human- & Biotechnology

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