Guerbet glycolipids from mannose: liquid crystals properties

Melonney Patrick, N. Idayu Zahid, Manfred Kriechbaum, Rauzah Hashim

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Using mannose as the sugar head, five Guerbet glycolipids with chain ranges from C8 to C24 were synthesised and studied for their liquid crystal behaviour. Differential scanning calorimetry, optical polarising microscopy and small-angle X-ray scattering were employed to determine the thermal, phase and structure properties. Unlike monoalkylated glycolipids, these Guerbet mannosides showed a glass transition below 0°C, except for α-Man-OC14C10. In the dry state, lamellar was observed for α-Man-OC6C2 and α-Man-OC8C4, while α-Man-OC12C8 and α-Man-OC14C10 formed non-lamellar phases, including inverse bicontinuous cubic phase of space group Ia3d and inverse hexagonal phase, respectively. The phase for middle-chain mannoside (α-Man-OC10C6) could not be assigned conclusively at room temperature, but this metastable phase forms lamellar above 37°C. The partial binary phase diagrams in water were also determined. Under excess water conditions at room and physiological temperatures, these materials form normal micellar solution, lamellar, inverse bicontinuous cubic of space group Pn3m and inverse hexagonal phases. The results were compared with those from other monosaccharide glycolipids from the same sugar Guerbet family. Although these compounds are obvious candidate material for lyotropic applications such as drug carrier and protein crystallisation medium, possible thermotropic application is now being explored.

Original languageEnglish
Pages (from-to)1970-1986
Number of pages17
JournalLiquid Crystals
Volume45
Issue number13-15
DOIs
Publication statusPublished - 2018

Fingerprint

Liquid Crystals
Glycolipids
Mannose
Mannosides
Liquid crystals
liquid crystals
Sugars
Drug Carriers
Metastable phases
Water
Monosaccharides
sugars
Crystallization
X ray scattering
Phase diagrams
Optical microscopy
Glass transition
Differential scanning calorimetry
Carrier Proteins
monosaccharides

Keywords

  • glycolipids
  • liquid crystal
  • Mannoside
  • metastable phase
  • non-lamellar phase
  • thermotropic cubic phase

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Guerbet glycolipids from mannose : liquid crystals properties. / Patrick, Melonney; Zahid, N. Idayu; Kriechbaum, Manfred; Hashim, Rauzah.

In: Liquid Crystals, Vol. 45, No. 13-15, 2018, p. 1970-1986.

Research output: Contribution to journalArticleResearchpeer-review

Patrick, Melonney ; Zahid, N. Idayu ; Kriechbaum, Manfred ; Hashim, Rauzah. / Guerbet glycolipids from mannose : liquid crystals properties. In: Liquid Crystals. 2018 ; Vol. 45, No. 13-15. pp. 1970-1986.
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