Gold nanoparticles in the engineering of antimicrobial and anticoagulant surfaces

Heike Ehmann, Doris Breitwieser, Sascha Winter, Christian Gspan, Günter Koraimann, Uros Maver, Marija Sega, Stefan Köstler, Karin Stana-Kleinschek, Volker Ribitsch, Stefan Spirk

Research output: Contribution to journalArticle

Abstract

Simultaneous antibacterial and anticoagulant surfaces have been prepared by immobilization of engineered gold nanoparticles onto different kinds of surfaces. The gold nanoparticle core is surrounded by a hemocompatible, anticoagulant polysaccharide, 6-O chitosan sulfate, which serves as reduction and stabilizing agent for the generation of gold nanoparticles in a microwave mediated reaction. The particle suspension shows anticoagulant activity, which is investigated by aPTT and PT testing on citrated blood samples of three patients suffering from congenital or acquired bleeding disorders. The amount of nanoparticles deposited on the surfaces is quantified by a quartz crystal microbalance with dissipation unit. All gold containing surfaces exhibit excellent antimicrobial properties against the chosen model organism, Escherichia coli MG 1655 [R1-16]. Moreover, blood plasma coagulation times of the surfaces are increased after deposition of the engineered nanoparticles as demonstrated by QCM-D.
Original languageEnglish
Pages (from-to)34-42
JournalCarbohydrate Polymers
Volume117
DOIs
Publication statusPublished - 2015

Fields of Expertise

  • Advanced Materials Science

Treatment code (Nähere Zuordnung)

  • Application

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