Functionalization of microarray devices: Process optimization using a multiobjective PSO and multiresponse MARS modeling

Laura Villanova*, Paolo Falcaro, Davide Carta, Irene Poli, Rob Hyndman, Kate Smith-Miles

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An evolutionary approach for the optimization of microarray coatings produced via sol-gel chemistry is presented. The aim of the methodology is to face the challenging aspects of the problem: unknown objective function, high dimensional variable space, constraints on the independent variables, multiple responses, expensive or time-consuming experimental trials, expected complexity of the functional relationships between independent and response variables. The proposed approach iteratively selects a set of experiments by combining a multiob-jective Particle Swarm Optimization (PSO) and a multiresponse Multivariate Adaptive Regression Splines (MARS) model. At each iteration of the algorithm the selected experiments are implemented and evaluated, and the system response is used as a feedback for the selection of the new trials. The performance of the approach is measured in terms of improvements with respect to the best coating obtained changing one variable at a time (the method typically used by scientists). Relevant enhancements have been detected, and the proposed evolutionary approach is shown to be a useful methodology for process optimization with great promise for industrial applications.

Original languageEnglish
Title of host publication2010 IEEE World Congress on Computational Intelligence, WCCI 2010 - 2010 IEEE Congress on Evolutionary Computation, CEC 2010
DOIs
Publication statusPublished - 2010
Externally publishedYes
Event2010 6th IEEE World Congress on Computational Intelligence, WCCI 2010 - 2010 IEEE Congress on Evolutionary Computation, CEC 2010 - Barcelona, Spain
Duration: 18 Jul 201023 Jul 2010

Conference

Conference2010 6th IEEE World Congress on Computational Intelligence, WCCI 2010 - 2010 IEEE Congress on Evolutionary Computation, CEC 2010
CountrySpain
CityBarcelona
Period18/07/1023/07/10

ASJC Scopus subject areas

  • Computational Theory and Mathematics
  • Applied Mathematics

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