Functionalization of AFM tips for use in force spectroscopy between polymers and model surfaces

Tina Maver, Karin Stana-Kleinschek, Zdenka Peršin, Uroš Maver*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

The following work presents the use of two different methods for the attachment of different functional groups onto the AFM tip surface. Such functionalized tips then allow for further binding of molecules with different origins and natures, thus allowing for use when measuring forces, and the extent of interactions appearing between two model surfaces and in real systems. Force spectroscopy, in combination with chemical force microscopy (CFM), as used in this study, exhibits great potential for chemical sensing in the field of polymer sciences. In modern wound treatment, it is very important to know the type and ranges of interactions between different polymer materials, which are mostly crucial components of the dressings. Precise measurement of these interactions would help to choose those materials that fit together without the use of additional chemical modifications on their surfaces. Such modifications are often the cause of unpredictable complications during the course of wound healing. This same method could also be used for interaction evaluation between chosen polymer materials with biological macromolecules, which appear within the wound during the healing process. Such in vitro testing could be of great help when optimal wound dressing materials need to be chosen in order to alleviate a patient́s suffering after application. Scanning electron and atomic force microscopies were used in order to prove the effectiveness and applicability of the used functionalization procedures.

Original languageEnglish
Pages (from-to)205-211
Number of pages7
JournalMateriali in Tehnologije
Volume45
Issue number3
Publication statusPublished - 1 May 2011
Externally publishedYes

Keywords

  • Atomic force microscopy
  • Chemical force microscopy
  • Force spectroscopy
  • Functionalization of AFM tips

ASJC Scopus subject areas

  • Polymers and Plastics
  • Metals and Alloys

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