Formation of potentially toxic carbonyls during oxidation of triolein in the presence of alimentary antioxidants

Marini Damanik; Michael Murkovic

doi:10.1007/s00706-017-2036-3

Formation of potentially toxic carbonyls during oxidation of triolein in the presence of alimentary antioxidants

Marini Damanik^*, Michael Murkovic

^*Corresponding author for this work

Institute of Biochemistry (6480)

Research output: Contribution to journal › Article › peer-review

Abstract

Abstract: A relation between oil uptake and cancer as well as induction of hepatic inflammation was shown earlier. It is discussed that the main oil oxidation products—hydroperoxides and carbonyls—might be the reason for the mentioned diseases. In this manuscript quantitative determination of aldehydes which are formed during oxidation of triolein—as a model substance—using the Rancimat 679 is described. The oxidation of 11 g of triolein is carried out at 120 °C sparging air with a flow of 20 dm³/h for 10 h. A series of aliphatic aldehydes starting from hexanal to decanal as well as decenal was identified by LC–MS/MS and quantified as DNPH derivatives. In addition, the total amount of carbonyls was determined. Based on the calibration with hexanal, all other dominant substances were in the similar concentration range with maximum concentrations of 1.6 µmol/cm³ of hexanal, 2.3 µmol/cm³ of heptanal, 2.5 µmol/cm³ of octanal, 3.2 µmol/cm³ of nonanal, 4.0 µmol/cm³ of decanal after 6 h. The total amount of carbonyls reached a maximum after 6 h being 27 µmol/cm³ for triolein without antioxidant. The results of this investigation will be a basis for further toxicological studies on oxidized oils.

Original language	English
Pages (from-to)	2031-2035
Number of pages	5
Journal	Monatshefte für Chemie - Chemical Monthly
Volume	148
Issue number	12
DOIs	https://doi.org/10.1007/s00706-017-2036-3
Publication status	Published - 1 Dec 2017

Keywords

Aldehydes
Antioxidants
DNPH
Lipid oxidation
Triolein
α-Tocopherol
β-Carotene

ASJC Scopus subject areas

General Chemistry

Fields of Expertise

Human- & Biotechnology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00706-017-2036-3Licence: CC BY 4.0

Cite this

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title = "Formation of potentially toxic carbonyls during oxidation of triolein in the presence of alimentary antioxidants",

abstract = "Abstract: A relation between oil uptake and cancer as well as induction of hepatic inflammation was shown earlier. It is discussed that the main oil oxidation products—hydroperoxides and carbonyls—might be the reason for the mentioned diseases. In this manuscript quantitative determination of aldehydes which are formed during oxidation of triolein—as a model substance—using the Rancimat 679 is described. The oxidation of 11 g of triolein is carried out at 120 °C sparging air with a flow of 20 dm3/h for 10 h. A series of aliphatic aldehydes starting from hexanal to decanal as well as decenal was identified by LC–MS/MS and quantified as DNPH derivatives. In addition, the total amount of carbonyls was determined. Based on the calibration with hexanal, all other dominant substances were in the similar concentration range with maximum concentrations of 1.6 µmol/cm3 of hexanal, 2.3 µmol/cm3 of heptanal, 2.5 µmol/cm3 of octanal, 3.2 µmol/cm3 of nonanal, 4.0 µmol/cm3 of decanal after 6 h. The total amount of carbonyls reached a maximum after 6 h being 27 µmol/cm3 for triolein without antioxidant. The results of this investigation will be a basis for further toxicological studies on oxidized oils.",

keywords = "Aldehydes, Antioxidants, DNPH, Lipid oxidation, Triolein, α-Tocopherol, β-Carotene",

author = "Marini Damanik and Michael Murkovic",

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T1 - Formation of potentially toxic carbonyls during oxidation of triolein in the presence of alimentary antioxidants

AU - Damanik, Marini

AU - Murkovic, Michael

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Abstract: A relation between oil uptake and cancer as well as induction of hepatic inflammation was shown earlier. It is discussed that the main oil oxidation products—hydroperoxides and carbonyls—might be the reason for the mentioned diseases. In this manuscript quantitative determination of aldehydes which are formed during oxidation of triolein—as a model substance—using the Rancimat 679 is described. The oxidation of 11 g of triolein is carried out at 120 °C sparging air with a flow of 20 dm3/h for 10 h. A series of aliphatic aldehydes starting from hexanal to decanal as well as decenal was identified by LC–MS/MS and quantified as DNPH derivatives. In addition, the total amount of carbonyls was determined. Based on the calibration with hexanal, all other dominant substances were in the similar concentration range with maximum concentrations of 1.6 µmol/cm3 of hexanal, 2.3 µmol/cm3 of heptanal, 2.5 µmol/cm3 of octanal, 3.2 µmol/cm3 of nonanal, 4.0 µmol/cm3 of decanal after 6 h. The total amount of carbonyls reached a maximum after 6 h being 27 µmol/cm3 for triolein without antioxidant. The results of this investigation will be a basis for further toxicological studies on oxidized oils.

AB - Abstract: A relation between oil uptake and cancer as well as induction of hepatic inflammation was shown earlier. It is discussed that the main oil oxidation products—hydroperoxides and carbonyls—might be the reason for the mentioned diseases. In this manuscript quantitative determination of aldehydes which are formed during oxidation of triolein—as a model substance—using the Rancimat 679 is described. The oxidation of 11 g of triolein is carried out at 120 °C sparging air with a flow of 20 dm3/h for 10 h. A series of aliphatic aldehydes starting from hexanal to decanal as well as decenal was identified by LC–MS/MS and quantified as DNPH derivatives. In addition, the total amount of carbonyls was determined. Based on the calibration with hexanal, all other dominant substances were in the similar concentration range with maximum concentrations of 1.6 µmol/cm3 of hexanal, 2.3 µmol/cm3 of heptanal, 2.5 µmol/cm3 of octanal, 3.2 µmol/cm3 of nonanal, 4.0 µmol/cm3 of decanal after 6 h. The total amount of carbonyls reached a maximum after 6 h being 27 µmol/cm3 for triolein without antioxidant. The results of this investigation will be a basis for further toxicological studies on oxidized oils.

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KW - Antioxidants

KW - DNPH

KW - Lipid oxidation

KW - Triolein

KW - α-Tocopherol

KW - β-Carotene

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Formation of potentially toxic carbonyls during oxidation of triolein in the presence of alimentary antioxidants

Abstract

Keywords

ASJC Scopus subject areas

Fields of Expertise

UN SDGs

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