Filling of lactose-based formulations in a tamping-pin capsule filler

Eva Faulhammer, Julia Kruisz, Otto Scheibelhofer, Jakob Rehrl, Andreas Witschnigg, Johannes G. Khinast*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

We studied three lactose-based formulations in terms of bulk powder properties and capsule-filling behavior in a tamping-pin capsule filling system, to which several mechanical adaptions were made for process optimization in light of future continuous production. The model formulations were thoroughly characterized and filled into size 1 capsules according a well-defined design of experiments (DoE). Overall, the three entirely different formulations were successfully filled within the selected design space. The fill weight and fill weight variability can be adjusted by fine-tuning the process settings, like the pin immersion depth and the maximum compaction pressure (pneumatic or spring-controlled), and by using the appropriate powder bed height and mechanical adaptions. This study demonstrated that selection of process parameters and mechanical adaptions could enhance the filling performance, especially in continuous production, since they reduce the powder volume in the process. Moreover, we showed that a tamping-pin system is capable of successfully filling a broad range of powders with various material characteristics and can potentially be used in a continuous production mode.
Original languageEnglish
Pages (from-to)775-787
Number of pages13
JournalDrug Development and Industrial Pharmacy
Volume46
Issue number5
Early online date17 Apr 2020
DOIs
Publication statusPublished - May 2020

Keywords

  • continuous manufacturing
  • lactose-based formulations
  • material characterization
  • process optimization
  • Tamping-pin capsule filling

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

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