Lightweight-design of welded high-strength steel structures in cyclic service necessitates the use of post-treatment methods like the high frequency mechanical impact treatment (HFMI). Service loads during operation mostly consist of variable amplitudes, whereat recommendations are only available for the as-welded condition. Therefore, this paper deals with the effect of variable amplitude block loading on the fatigue strength of HFMI-treated T-joints. An evaluation of the real damage sum exhibits characteristic distinctions to constant amplitude test results in regard to the base material strength. The application of an equivalent stress range method by nominal and effective notch stress approach is finally presented.