A panel of human flavin monooxygenases were heterologously expressed in E. coli to obtain ready-to-use biocatalysts for the in vitro preparation of human drug metabolites. Moclobemide-N-oxide (65 mg) was the first high-priced metabolite prepared with recombinant hFMO3 on the multi-milligram scale.
- Escherichia coli
- Mixed Function Oxygenases
- Journal Article
- Research Support, Non-U.S. Gov't
Fields of Expertise
- Human- & Biotechnology
Treatment code (Nähere Zuordnung)