Experimental and numerical investigations of the RTD in a GEA ConsiGma CTL25 tablet press

T. Forgber; J. Rehrl; M. Matic; R. Sibanc; R. Sivanesapillai; J. G. Khinast

doi:10.1016/j.powtec.2022.117507

Experimental and numerical investigations of the RTD in a GEA ConsiGma CTL25 tablet press

T. Forgber^*, J. Rehrl, M. Matic, R. Sibanc, R. Sivanesapillai, J. G. Khinast

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A discrete element model (DEM) for the prediction of residence time distributions (RTD) in a tablet press operation is validated. To this end, a Design-of-Experiment (DoE) study was performed on the Courtoy Modul P tablet press, and RTD data was gathered using optical measurement of a tracer for various process conditions. Flowability and compressibility of the powder were measured and used for DEM calibration. DEM predictions for RTD exhibit an overall good agreement with DoE ground truth data. The highest relative error for mean residence time amounted to 10% and was observed for the low mass flow edge case. Further, a detailed investigation of the granular flow was carried out with a focus on dead flow regions and mixing behavior in the feed paddle region.

Original language	English
Article number	117507
Journal	Powder Technology
Volume	405
DOIs	https://doi.org/10.1016/j.powtec.2022.117507
Publication status	Published - Jun 2022

Keywords

Discrete element method (DEM)
Residence time distribution (RTD)
Simulation
Tablet press
Validaiton

ASJC Scopus subject areas

Chemical Engineering(all)

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10.1016/j.powtec.2022.117507

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@article{00827a4f55cb45fba701568ae5c3358e,

title = "Experimental and numerical investigations of the RTD in a GEA ConsiGma CTL25 tablet press",

abstract = "A discrete element model (DEM) for the prediction of residence time distributions (RTD) in a tablet press operation is validated. To this end, a Design-of-Experiment (DoE) study was performed on the Courtoy Modul P tablet press, and RTD data was gathered using optical measurement of a tracer for various process conditions. Flowability and compressibility of the powder were measured and used for DEM calibration. DEM predictions for RTD exhibit an overall good agreement with DoE ground truth data. The highest relative error for mean residence time amounted to 10% and was observed for the low mass flow edge case. Further, a detailed investigation of the granular flow was carried out with a focus on dead flow regions and mixing behavior in the feed paddle region.",

keywords = "Discrete element method (DEM), Residence time distribution (RTD), Simulation, Tablet press, Validaiton",

author = "T. Forgber and J. Rehrl and M. Matic and R. Sibanc and R. Sivanesapillai and Khinast, {J. G.}",

note = "Funding Information: This work was funded through Bayer AG. The Research Center Pharmaceutical Engineering (RCPE) is funded within the framework of COMET - Competence Centers for Excellent Technologies by BMK, BMDW, Land Steiermark, and SFG. The COMET program is managed by the FFG. Funding Information: This work was funded through Bayer AG . The Research Center Pharmaceutical Engineering (RCPE) is funded within the framework of COMET - Competence Centers for Excellent Technologies by BMK, BMDW, Land Steiermark, and SFG. The COMET program is managed by the FFG. Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = jun,

doi = "10.1016/j.powtec.2022.117507",

language = "English",

volume = "405",

journal = "Powder Technology",

issn = "0032-5910",

publisher = "Elsevier B.V.",

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T1 - Experimental and numerical investigations of the RTD in a GEA ConsiGma CTL25 tablet press

AU - Forgber, T.

AU - Rehrl, J.

AU - Matic, M.

AU - Sibanc, R.

AU - Sivanesapillai, R.

AU - Khinast, J. G.

N1 - Funding Information: This work was funded through Bayer AG. The Research Center Pharmaceutical Engineering (RCPE) is funded within the framework of COMET - Competence Centers for Excellent Technologies by BMK, BMDW, Land Steiermark, and SFG. The COMET program is managed by the FFG. Funding Information: This work was funded through Bayer AG . The Research Center Pharmaceutical Engineering (RCPE) is funded within the framework of COMET - Competence Centers for Excellent Technologies by BMK, BMDW, Land Steiermark, and SFG. The COMET program is managed by the FFG. Publisher Copyright: © 2022

PY - 2022/6

Y1 - 2022/6

N2 - A discrete element model (DEM) for the prediction of residence time distributions (RTD) in a tablet press operation is validated. To this end, a Design-of-Experiment (DoE) study was performed on the Courtoy Modul P tablet press, and RTD data was gathered using optical measurement of a tracer for various process conditions. Flowability and compressibility of the powder were measured and used for DEM calibration. DEM predictions for RTD exhibit an overall good agreement with DoE ground truth data. The highest relative error for mean residence time amounted to 10% and was observed for the low mass flow edge case. Further, a detailed investigation of the granular flow was carried out with a focus on dead flow regions and mixing behavior in the feed paddle region.

AB - A discrete element model (DEM) for the prediction of residence time distributions (RTD) in a tablet press operation is validated. To this end, a Design-of-Experiment (DoE) study was performed on the Courtoy Modul P tablet press, and RTD data was gathered using optical measurement of a tracer for various process conditions. Flowability and compressibility of the powder were measured and used for DEM calibration. DEM predictions for RTD exhibit an overall good agreement with DoE ground truth data. The highest relative error for mean residence time amounted to 10% and was observed for the low mass flow edge case. Further, a detailed investigation of the granular flow was carried out with a focus on dead flow regions and mixing behavior in the feed paddle region.

KW - Discrete element method (DEM)

KW - Residence time distribution (RTD)

KW - Simulation

KW - Tablet press

KW - Validaiton

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DO - 10.1016/j.powtec.2022.117507

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JO - Powder Technology

JF - Powder Technology

SN - 0032-5910

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ER -

Experimental and numerical investigations of the RTD in a GEA ConsiGma CTL25 tablet press

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Keywords

ASJC Scopus subject areas

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