Evolutionary conserved networks of human height identify multiple Mendelian causes of short stature

Nadine N Hauer, Bernt Popp, Leila Taher, Carina Vogl, Perundurai S Dhandapany, Christian Büttner, Steffen Uebe, Heinrich Sticht, Fulvia Ferrazzi, Arif B Ekici, Alessandro De Luca, Patrizia Klinger, Cornelia Kraus, Christiane Zweier, Antje Wiesener, Rami Abou Jamra, Erdmute Kunstmann, Anita Rauch, Dagmar Wieczorek, Anna-Marie JungTilman R Rohrer, Martin Zenker, Helmuth-Guenther Doerr, André Reis, Christian T Thiel

Research output: Contribution to journalArticle

Abstract

Height is a heritable and highly heterogeneous trait. Short stature affects 3% of the population and in most cases is genetic in origin. After excluding known causes, 67% of affected individuals remain without diagnosis. To identify novel candidate genes for short stature, we performed exome sequencing in 254 unrelated families with short stature of unknown cause and identified variants in 63 candidate genes in 92 (36%) independent families. Based on systematic characterization of variants and functional analysis including expression in chondrocytes, we classified 13 genes as strong candidates. Whereas variants in at least two families were detected for all 13 candidates, two genes had variants in 6 (UBR4) and 8 (LAMA5) families, respectively. To facilitate their characterization, we established a clustered network of 1025 known growth and short stature genes, which yielded 29 significantly enriched clusters, including skeletal system development, appendage development, metabolic processes, and ciliopathy. Eleven of the candidate genes mapped to 21 of these clusters, including CPZ, EDEM3, FBRS, IFT81, KCND1, PLXNA3, RASA3, SLC7A8, UBR4, USP45, and ZFHX3. Fifty additional growth-related candidates we identified await confirmation in other affected families. Our study identifies Mendelian forms of growth retardation as an important component of idiopathic short stature.

Original languageEnglish
Pages (from-to)1061-1071
Number of pages11
JournalEuropean Journal of Human Genetics
Volume27
Issue number7
DOIs
Publication statusPublished - Jul 2019

Fields of Expertise

  • Human- & Biotechnology

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