Efficient Encapsulation of Fluorinated Drugs in the Confined Space of Water-Dispersible Fluorous Supraparticles

Claudia Pigliacelli, Daniele Maiolo, Nonappa Nonappa, Johannes S. Haataja, Heinz Amenitsch, Claire Michelet, Paola Sánchez Moreno, Ilaria Tirotta, Pierangelo Metrangolo, Francesca Baldelli Bombelli

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Fluorophobic-driven assemblies of gold nanomaterials were stabilized into water-dispersible fluorous supraparticles by the film-forming protein hydrophobin II. The strategy makes use of fluorous nanomaterials of different dimensions to engineer size and inner functionalization of the resulting confined space. The inner fluorous compartments allow efficient encapsulation and transport of high loadings of partially fluorinated drug molecules in water.

Original languageEnglish
Pages (from-to)16186-16190
Number of pages5
JournalAngewandte Chemie / International Edition
Volume56
Issue number51
DOIs
Publication statusPublished - 18 Dec 2017

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Keywords

  • fluorous surfaces
  • gold nanoparticles
  • hydrophobin
  • self-assembly
  • supraparticles

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fields of Expertise

  • Advanced Materials Science
  • Human- & Biotechnology

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