Efficient Discrete Element Method Simulation Strategy for Analyzing Large-Scale Agitated Powder Mixers

Eva Siegmann, Dalibor Jajcevic, Charles Radeke, Dieter Strube, Karsten Friedrich, Johannes G. Khinast

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Powder mixing is one of the most important pharmaceutical manufacturing operations. Computation methods are required to transform mixer design and scale-up from art to science. Due to an increase in the computational power and the development of graphics cards, the discrete element method is becoming a widely-used technique. For an industrial granular mixer, it is demonstrated that a smart simulation strategy together with a highly efficient code can reduce the simulation time. The good agreement between simulation and measurement data confirms that the simulation strategy can be applied to the product development.

Original languageEnglish
Pages (from-to)995-1005
Number of pages11
JournalChemie - Ingenieur - Technik
Volume89
Issue number8
DOIs
Publication statusPublished - 1 Aug 2017

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Keywords

  • Blending
  • Discrete element method
  • Granular flow
  • Mixing
  • Scaling

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering

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