Effect of Acetonitrile-Based Crystallization Conditions on the Crystal Quality of Vitamin D3

Heidrun Gruber-Woelfler, Marc Escribà-Gelonch, Timothy Noël, Manuel C. Maier, Volker Hessel

Research output: Contribution to journalArticleResearchpeer-review

Abstract

To design an integrated continuous crystallization setup that is directly coupled to a photochemical synthesis in flow, the crystallization of vitamin D3 was studied in detail. Because of the high solubility of the vitamin in the reaction solvent tert-butylmethyl ether, a solvent swap to acetonitrile was necessary. While other methods use a multistep procedure, with the proposed approach, crystalline vitamin D3 can be obtained within one crystallization step. The influence of crystallization parameters, such as the initial concentration of vitamin D3, stirring as well as cooling temperature, rate, and time, on the obtained results in terms of yield, crystal shape, polymorphism, and particle size distribution are discussed in detail.

Original languageEnglish
Pages (from-to)2016-2024
Number of pages9
JournalChemical Engineering & Technology
Volume40
Issue number11
DOIs
Publication statusPublished - 1 Nov 2017

Fingerprint

Vitamins
Crystallization
Acetonitrile
Cholecalciferol
Crystals
Polymorphism
Particle size analysis
Ether
Ethers
Solubility
Crystalline materials
Cooling
acetonitrile
Temperature

Keywords

  • Crystallization
  • Polymorphism
  • Solubility
  • Vitamin D

Fields of Expertise

  • Advanced Materials Science

Cite this

Effect of Acetonitrile-Based Crystallization Conditions on the Crystal Quality of Vitamin D3. / Gruber-Woelfler, Heidrun; Escribà-Gelonch, Marc; Noël, Timothy; Maier, Manuel C.; Hessel, Volker.

In: Chemical Engineering & Technology, Vol. 40, No. 11, 01.11.2017, p. 2016-2024.

Research output: Contribution to journalArticleResearchpeer-review

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