TY - JOUR
T1 - Development of a Workflow to Engineer Tailored Microparticles Via Inkjet Printing
AU - Winter, Christina
AU - Zettl, Manuel
AU - Mantanus, Jérôme
AU - Hadjittofis, Eftychios
AU - Leitinger, Gerd
AU - Kolb, Dagmar
AU - Hsiao, Wen Kai
AU - Spoerk, Martin
AU - Paudel, Amrit
AU - Roblegg, Eva
AU - Pinto, Joana T.
N1 - Funding Information:
The Research Center Pharmaceutical Engineering (RCPE) is funded within the framework of COMET—Competence Centers for Excellent Technologies by BMK, BMAW, Land Steiermark and SFG. The COMET program is managed by the FFG.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023
Y1 - 2023
N2 - Purpose: New drug development and delivery approaches result in an ever-increasing demand for tailored microparticles with defined sizes and structures. Inkjet printing technologies could be promising new processes to engineer particles with defined characteristics, as they are created to precisely deliver liquid droplets with high uniformity. Methods: D-mannitol was used as a model compound alone or co-processed with the pore former agent ammonium bicarbonate, and the polymer polyethylene glycol 200. Firstly, a drop shape analyzer was used to characterize and understand ink/substrate interactions, evaporation, and solidification kinetics. Consequently, the process was transferred to a laboratory-scale inkjet printer and the resulting particles collected, characterized and compared to others obtained via an industrial standard technique. Results: The droplet shape analysis allowed to understand how 3D structures are formed and helped define the formulation and process parameters for inkjet printing. By adjusting the drop number and process waveform, spherical particles with a mean size of approximately 100 µm were obtained. The addition of pore former and polymer allowed to tailor the crystallization kinetics, resulting in particles with a different surface (i.e., spike-like surface) and bulk (e.g. porous and non-porous) structure. Conclusion: The workflow described enabled the production of 3D structures via inkjet printing, demonstrating that this technique can be a promising approach to engineer microparticles.
AB - Purpose: New drug development and delivery approaches result in an ever-increasing demand for tailored microparticles with defined sizes and structures. Inkjet printing technologies could be promising new processes to engineer particles with defined characteristics, as they are created to precisely deliver liquid droplets with high uniformity. Methods: D-mannitol was used as a model compound alone or co-processed with the pore former agent ammonium bicarbonate, and the polymer polyethylene glycol 200. Firstly, a drop shape analyzer was used to characterize and understand ink/substrate interactions, evaporation, and solidification kinetics. Consequently, the process was transferred to a laboratory-scale inkjet printer and the resulting particles collected, characterized and compared to others obtained via an industrial standard technique. Results: The droplet shape analysis allowed to understand how 3D structures are formed and helped define the formulation and process parameters for inkjet printing. By adjusting the drop number and process waveform, spherical particles with a mean size of approximately 100 µm were obtained. The addition of pore former and polymer allowed to tailor the crystallization kinetics, resulting in particles with a different surface (i.e., spike-like surface) and bulk (e.g. porous and non-porous) structure. Conclusion: The workflow described enabled the production of 3D structures via inkjet printing, demonstrating that this technique can be a promising approach to engineer microparticles.
KW - D-mannitol
KW - excipient
KW - inkjet printing
KW - microparticles
KW - particle engineering
KW - spray drying
UR - http://www.scopus.com/inward/record.url?scp=85141945992&partnerID=8YFLogxK
U2 - 10.1007/s11095-022-03426-4
DO - 10.1007/s11095-022-03426-4
M3 - Article
AN - SCOPUS:85141945992
SN - 0724-8741
VL - 40
SP - 281
EP - 294
JO - Pharmaceutical Research
JF - Pharmaceutical Research
IS - 1
ER -