Weiterentwicklung einer Mikroperfusionspumpe für die klinische Anwendung

Translated title of the contribution: Development of a Microperfusionpump for clinical application

Madlen Hernach

Research output: ThesisMaster's Thesis

Abstract

The Open Flow Microperfusion (OFM) is a minimally invasive sampling technology that
provides essential information on pharmacokinetics and pharmacodynamics in the target
tissue, at early stages of drug development. The aim of this work is the further development of
the Microperfusionpump MPP101 to improve the stability of this sampling technology. The
Microperfusionpump MPP101 is a peristaltic pump which is certified according to Medical
Device Directive 93/42/EWG and provides flow rates in the range of 0.1 to 10μl/min. Primary
aims of this development were to increase the reliability of use and to reduce the frequency of
maintenance. By creating a functional structure and identifying the important characteristics
of the pump, different solutions were sought to fix the existing difficulties. On the basis of
experiments, alternative drive units, power supplies und sliding materials were tested and
evaluated and finally combined into an overall solution. This overall solution was
implemented in a prototype and tested in a final check on the requirements specified at the
start of the work. This final check showed that the reliability and durability of the pump were
successfully increased.
Translated title of the contribution Development of a Microperfusionpump for clinical application
Original languageGerman
QualificationMaster of Science
Awarding Institution
  • Graz University of Technology (90000)
Supervisors/Advisors
  • Scharfetter, Hermann, Supervisor
  • Priedl, Joachim, Supervisor, External person
  • Schaller-Ammann, Roland, Supervisor, External person
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Open Flow Microperfusion
  • peristaltic pump
  • medical device development

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