Design of anticoagulant surfaces based on cellulose nanocrystals

Heike Ehmann, Tamilselvan Mohan, Maria Koshanskaya, Sylvia Scheicher, Doris Breitwieser, Volker Ribitsch, Karin Stana-Kleinschek, Stefan Spirk

Research output: Contribution to journalArticle

Abstract

The anticoagulant activity of surfaces decorated with cellulose nanocrystals (CNCs) prepared via sulfuric acid hydrolysis, is explored. Such surfaces bear a high amount of negatively charged sulfate groups, which mimic the naturally occurring anticoagulant heparin in terms of charge density. It is demonstrated that CNC decorated surfaces significantly enhance the coagulation times of blood plasma and whole blood as proven by QCM-D and simple clotting tests.
Original languageEnglish
Pages (from-to)13070-2
JournalChemical Communications
Volume50
Issue number86
DOIs
Publication statusPublished - 2014

Fields of Expertise

  • Advanced Materials Science

Treatment code (Nähere Zuordnung)

  • Application

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