Creation of a lipase highly selective for trans fatty acids by protein engineering

Henrike B Brundiek, Andrew S Evitt, Robert Kourist, Uwe T Bornscheuer

Research output: Contribution to journalArticle

Abstract

Sorting out: Protein engineering of lipase CAL-A led to the discovery of mutants with excellent chemoselectivity for the removal of trans and saturated fatty acids from partially hydrogenated vegetable oil. These fatty acids, identified as a major risk factor for human health, can now be removed by enzyme catalysis.

LanguageEnglish
Pages412-4
Number of pages3
JournalAngewandte Chemie (Weinheim) / International edition in English
Volume51
Issue number2
DOIs
StatusPublished - 9 Jan 2012

Fingerprint

Saturated fatty acids
Trans Fatty Acids
Vegetable oils
Lipases
Lipase
Sorting
Fatty acids
Catalysis
Fatty Acids
Enzymes
Health
Proteins
Plant Oils

Keywords

  • Candida
  • Hydrogenation
  • Lipase
  • Models, Molecular
  • Mutation
  • Protein Engineering
  • Trans Fatty Acids
  • Journal Article

Fields of Expertise

  • Human- & Biotechnology

Cite this

Creation of a lipase highly selective for trans fatty acids by protein engineering. / Brundiek, Henrike B; Evitt, Andrew S; Kourist, Robert; Bornscheuer, Uwe T.

In: Angewandte Chemie (Weinheim) / International edition in English, Vol. 51, No. 2, 09.01.2012, p. 412-4.

Research output: Contribution to journalArticle

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