Creation of a lipase highly selective for trans fatty acids by protein engineering

Henrike B Brundiek, Andrew S Evitt, Robert Kourist, Uwe T Bornscheuer

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Sorting out: Protein engineering of lipase CAL-A led to the discovery of mutants with excellent chemoselectivity for the removal of trans and saturated fatty acids from partially hydrogenated vegetable oil. These fatty acids, identified as a major risk factor for human health, can now be removed by enzyme catalysis.

Original languageEnglish
Pages (from-to)412-4
Number of pages3
JournalAngewandte Chemie / International Edition
Volume51
Issue number2
DOIs
Publication statusPublished - 9 Jan 2012

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Keywords

  • Candida
  • Hydrogenation
  • Lipase
  • Models, Molecular
  • Mutation
  • Protein Engineering
  • Trans Fatty Acids
  • Journal Article

Fields of Expertise

  • Human- & Biotechnology

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