Controlling Indomethacin Release through Vapor-Phase Deposited Hydrogel Films by Adjusting the Cross-linker Density

Paul Christian, Stephan Tumphart, Heike M.A. Ehmann, Hans Riegler, Anna Maria Coclite, Oliver Werzer

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Vapor-phase deposited polymer coatings are applied on thin indomethacin films to modify the drug release. Hydrogel-forming co-polymers of 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate were prepared directly on top of solution cast indomethacin thin films by initiated Chemical Vapor Deposition (iCVD). This technique allows for solvent-free processing under mild conditions, thus minimizing a potential impact on the pharmaceutical. The drug release behavior, among other properties, was evaluated for polymers of different compositions and at different temperatures. The data show that the release kinetics can be tuned by several orders of magnitude as the cross-linker fraction is varied in the polymer coating. While uncoated indomethacin films were fully released within an hour, polymer coatings showed gradual liberation over several hours to days. Additional insight is gained from evaluating the experimental dissolution data in the framework of diffusive transport. The results of this study show that the iCVD technique has some promises for pharmaceutical technology, potentially allowing for tailored release behavior also for other drug systems.

Original languageEnglish
Article number7134
JournalScientific reports
Volume8
Issue number1
DOIs
Publication statusPublished - 1 Dec 2018

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Indomethacin
Polymers
Vapors
Pharmaceutical Preparations
Coatings
Chemical vapor deposition
Thin films
Hydrogel
Dissolution
hydrogel film
Kinetics
Processing
Chemical analysis
Temperature

ASJC Scopus subject areas

  • General

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Controlling Indomethacin Release through Vapor-Phase Deposited Hydrogel Films by Adjusting the Cross-linker Density. / Christian, Paul; Tumphart, Stephan; Ehmann, Heike M.A.; Riegler, Hans; Coclite, Anna Maria; Werzer, Oliver.

In: Scientific reports, Vol. 8, No. 1, 7134, 01.12.2018.

Research output: Contribution to journalArticleResearchpeer-review

Christian, Paul ; Tumphart, Stephan ; Ehmann, Heike M.A. ; Riegler, Hans ; Coclite, Anna Maria ; Werzer, Oliver. / Controlling Indomethacin Release through Vapor-Phase Deposited Hydrogel Films by Adjusting the Cross-linker Density. In: Scientific reports. 2018 ; Vol. 8, No. 1.
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