Controlling concentration of bioactive components in cat's claw based products with a hybrid separation process

Alba Calvo, Dániel Dévényi, Bence Kószó, Sergio Sanz, Anna Lisa Oelbermann, Markus Maier, Tibor Keve, Kinga Komka, Thomas Gamse, Eckhard Weidner, Edit Székely

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Supercritical fluid extraction (SFE) with and without entrainer combined with organic solvent extraction was used for fractionation of bioactive natural products as alkaloids and antioxidants from cat's claw (Uncaria tomentosa (Willd.) DC.) bark. Extracts obtained from this plant have a number of beneficial effects, including anti-inflammatory or immune stimulator. The aim of this work was to obtain extracts of enriched and limited alkaloid concentrations, good antioxidants and tannin agents. The results demonstrated that a hybrid process involving SFE is a selective method to obtain an oxindole alkaloid rich fraction (186.0 ± 3.2 mg total pentacyclic oxindole alkaloids/g extract) and a product enriched in tannins (23.8 ± 1.9% tannin content in extract) and antioxidants (IC50 = 5.88 ± 0.54 μg/ml extract).

Original languageEnglish
Pages (from-to)50-55
Number of pages6
JournalJournal of Supercritical Fluids
Volume125
DOIs
Publication statusPublished - 1 Jul 2017

Fingerprint

Alkaloids
alkaloids
cats
activity (biology)
Tannins
antioxidants
Antioxidants
Supercritical fluid extraction
supercritical fluids
products
solvent extraction
Plant Extracts
Solvent extraction
Fractionation
Biological Products
fractionation
Organic solvents
Anti-Inflammatory Agents
direct current
oxindole

Keywords

  • Antioxidants
  • Cat's claw
  • Co-solvent
  • Natural alkaloid
  • Supercritical fluid extraction
  • Tannins

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

Cite this

Controlling concentration of bioactive components in cat's claw based products with a hybrid separation process. / Calvo, Alba; Dévényi, Dániel; Kószó, Bence; Sanz, Sergio; Oelbermann, Anna Lisa; Maier, Markus; Keve, Tibor; Komka, Kinga; Gamse, Thomas; Weidner, Eckhard; Székely, Edit.

In: Journal of Supercritical Fluids, Vol. 125, 01.07.2017, p. 50-55.

Research output: Contribution to journalArticleResearchpeer-review

Calvo, A, Dévényi, D, Kószó, B, Sanz, S, Oelbermann, AL, Maier, M, Keve, T, Komka, K, Gamse, T, Weidner, E & Székely, E 2017, 'Controlling concentration of bioactive components in cat's claw based products with a hybrid separation process' Journal of Supercritical Fluids, vol. 125, pp. 50-55. https://doi.org/10.1016/j.supflu.2017.01.018
Calvo, Alba ; Dévényi, Dániel ; Kószó, Bence ; Sanz, Sergio ; Oelbermann, Anna Lisa ; Maier, Markus ; Keve, Tibor ; Komka, Kinga ; Gamse, Thomas ; Weidner, Eckhard ; Székely, Edit. / Controlling concentration of bioactive components in cat's claw based products with a hybrid separation process. In: Journal of Supercritical Fluids. 2017 ; Vol. 125. pp. 50-55.
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