Controlling concentration of bioactive components in cat's claw based products with a hybrid separation process

Alba Calvo; Dániel Dévényi; Bence Kószó; Sergio Sanz; Anna Lisa Oelbermann; Markus Maier; Tibor Keve; Kinga Komka; Thomas Gamse; Eckhard Weidner; Edit Székely

doi:10.1016/j.supflu.2017.01.018

Controlling concentration of bioactive components in cat's claw based products with a hybrid separation process

Alba Calvo, Dániel Dévényi, Bence Kószó, Sergio Sanz, Anna Lisa Oelbermann, Markus Maier, Tibor Keve, Kinga Komka, Thomas Gamse, Eckhard Weidner, Edit Székely^*

^*Corresponding author for this work

Institute of Chemical Engineering and Environmental Technology (6670)

Research output: Contribution to journal › Article › peer-review

Abstract

Supercritical fluid extraction (SFE) with and without entrainer combined with organic solvent extraction was used for fractionation of bioactive natural products as alkaloids and antioxidants from cat's claw (Uncaria tomentosa (Willd.) DC.) bark. Extracts obtained from this plant have a number of beneficial effects, including anti-inflammatory or immune stimulator. The aim of this work was to obtain extracts of enriched and limited alkaloid concentrations, good antioxidants and tannin agents. The results demonstrated that a hybrid process involving SFE is a selective method to obtain an oxindole alkaloid rich fraction (186.0 ± 3.2 mg total pentacyclic oxindole alkaloids/g extract) and a product enriched in tannins (23.8 ± 1.9% tannin content in extract) and antioxidants (IC₅₀ = 5.88 ± 0.54 μg/ml extract).

Original language	English
Pages (from-to)	50-55
Number of pages	6
Journal	The Journal of Supercritical Fluids
Volume	125
DOIs	https://doi.org/10.1016/j.supflu.2017.01.018
Publication status	Published - 1 Jul 2017

Keywords

Antioxidants
Cat's claw
Co-solvent
Natural alkaloid
Supercritical fluid extraction
Tannins

ASJC Scopus subject areas

Chemical Engineering(all)
Condensed Matter Physics
Physical and Theoretical Chemistry

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10.1016/j.supflu.2017.01.018

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title = "Controlling concentration of bioactive components in cat's claw based products with a hybrid separation process",

abstract = "Supercritical fluid extraction (SFE) with and without entrainer combined with organic solvent extraction was used for fractionation of bioactive natural products as alkaloids and antioxidants from cat's claw (Uncaria tomentosa (Willd.) DC.) bark. Extracts obtained from this plant have a number of beneficial effects, including anti-inflammatory or immune stimulator. The aim of this work was to obtain extracts of enriched and limited alkaloid concentrations, good antioxidants and tannin agents. The results demonstrated that a hybrid process involving SFE is a selective method to obtain an oxindole alkaloid rich fraction (186.0 ± 3.2 mg total pentacyclic oxindole alkaloids/g extract) and a product enriched in tannins (23.8 ± 1.9% tannin content in extract) and antioxidants (IC50 = 5.88 ± 0.54 μg/ml extract).",

keywords = "Antioxidants, Cat's claw, Co-solvent, Natural alkaloid, Supercritical fluid extraction, Tannins",

author = "Alba Calvo and D{\'a}niel D{\'e}v{\'e}nyi and Bence K{\'o}sz{\'o} and Sergio Sanz and Oelbermann, {Anna Lisa} and Markus Maier and Tibor Keve and Kinga Komka and Thomas Gamse and Eckhard Weidner and Edit Sz{\'e}kely",

year = "2017",

month = jul,

day = "1",

doi = "10.1016/j.supflu.2017.01.018",

language = "English",

volume = "125",

pages = "50--55",

journal = "The Journal of Supercritical Fluids",

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T1 - Controlling concentration of bioactive components in cat's claw based products with a hybrid separation process

AU - Calvo, Alba

AU - Dévényi, Dániel

AU - Kószó, Bence

AU - Sanz, Sergio

AU - Oelbermann, Anna Lisa

AU - Maier, Markus

AU - Keve, Tibor

AU - Komka, Kinga

AU - Gamse, Thomas

AU - Weidner, Eckhard

AU - Székely, Edit

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Supercritical fluid extraction (SFE) with and without entrainer combined with organic solvent extraction was used for fractionation of bioactive natural products as alkaloids and antioxidants from cat's claw (Uncaria tomentosa (Willd.) DC.) bark. Extracts obtained from this plant have a number of beneficial effects, including anti-inflammatory or immune stimulator. The aim of this work was to obtain extracts of enriched and limited alkaloid concentrations, good antioxidants and tannin agents. The results demonstrated that a hybrid process involving SFE is a selective method to obtain an oxindole alkaloid rich fraction (186.0 ± 3.2 mg total pentacyclic oxindole alkaloids/g extract) and a product enriched in tannins (23.8 ± 1.9% tannin content in extract) and antioxidants (IC50 = 5.88 ± 0.54 μg/ml extract).

AB - Supercritical fluid extraction (SFE) with and without entrainer combined with organic solvent extraction was used for fractionation of bioactive natural products as alkaloids and antioxidants from cat's claw (Uncaria tomentosa (Willd.) DC.) bark. Extracts obtained from this plant have a number of beneficial effects, including anti-inflammatory or immune stimulator. The aim of this work was to obtain extracts of enriched and limited alkaloid concentrations, good antioxidants and tannin agents. The results demonstrated that a hybrid process involving SFE is a selective method to obtain an oxindole alkaloid rich fraction (186.0 ± 3.2 mg total pentacyclic oxindole alkaloids/g extract) and a product enriched in tannins (23.8 ± 1.9% tannin content in extract) and antioxidants (IC50 = 5.88 ± 0.54 μg/ml extract).

KW - Antioxidants

KW - Cat's claw

KW - Co-solvent

KW - Natural alkaloid

KW - Supercritical fluid extraction

KW - Tannins

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DO - 10.1016/j.supflu.2017.01.018

M3 - Article

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SN - 0896-8446

VL - 125

SP - 50

EP - 55

JO - The Journal of Supercritical Fluids

JF - The Journal of Supercritical Fluids

ER -

Controlling concentration of bioactive components in cat's claw based products with a hybrid separation process

Abstract

Keywords

ASJC Scopus subject areas

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