Comparison of video analysis and simulations of a drum coating process

P. Boehling*, G. Toschkoff, R. Dreu, S. Just, P. Kleinebudde, A. Funke, H. Rehbaum, J. G. Khinast

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Tablet coating is a common unit operation in the pharmaceutical industry. To improve currently established processes, it is important to understand the influence of the process parameters on the coating quality. One of the critical parameters is the tablet velocity. In this work, numerical results are compared to results obtained experimentally. Tablet movement in the drums was simulated using the Discrete Element Method (DEM). The simulation parameters were adapted to fit the simulation to the experimental data. A comparison of the experimental and simulation results showed that the simulation correctly represents the real tablet velocity. A change in the velocity over time and its dependence on the rotation rates and the baffle position in the simulation were similar to the experimental results. In summary, simulations can improve the understanding of tablet coating processes and will thus provide insights into the underlying process mechanics, which cannot be obtained via ordinary experiments.

Original languageEnglish
Pages (from-to)72-81
Number of pages10
JournalEuropean Journal of Pharmaceutical Sciences
Volume104
DOIs
Publication statusPublished - 15 Jun 2017

Keywords

  • DEM
  • Experiments
  • Simulation
  • Tablet coating

ASJC Scopus subject areas

  • Pharmaceutical Science

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