Clinical evaluation of in silico planning and real-time simulation of hepatic radiofrequency ablation (ClinicIMPPACT Trial)

Michael Moche, Harald Busse, Jurgen Futterer, Camila A Hinestrosa, Daniel Seider, Philipp Brandmaier, Marina Kolesnik, Sjoerd Jenniskens, Roberto Blanco Sequeiros, Gaber Komar, Mika Pollari, Martin Eibisberger, Horst Rupert Portugaller, Philip Voglreiter, Ronan Flanagan, Panchatcharam Mariappan, Martin Reinhardt

Research output: Contribution to journalArticleResearchpeer-review

Abstract


Objectives
To evaluate the accuracy and clinical integrability of a comprehensive simulation tool to plan and predict radiofrequency ablation (RFA) zones in liver tumors.
Methods
Forty-five patients with 51 malignant hepatic lesions of different origins were included in a prospective multicenter trial. Prior to CT-guided RFA, all patients underwent multiphase CT which included acquisitions for the assessment of liver perfusion. These data were used to generate a 3D model of the liver. The intra-procedural position of the RFA probe was determined by CT and semi-automatically registered to the 3D model. Size and shape of the simulated ablation zones were compared with those of the thermal ablation zones segmented in contrast-enhanced CT images 1 month after RFA; procedure time was compared with a historical control group …
Original languageEnglish
Number of pages9
JournalEuropean Radiology
DOIs
Publication statusE-pub ahead of print - 2019

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Computer Simulation
Liver
Multicenter Studies
Perfusion
Hot Temperature
Control Groups
Neoplasms

Cite this

Clinical evaluation of in silico planning and real-time simulation of hepatic radiofrequency ablation (ClinicIMPPACT Trial). / Moche, Michael; Busse, Harald; Futterer, Jurgen; A Hinestrosa, Camila; Seider, Daniel; Brandmaier, Philipp; Kolesnik, Marina; Jenniskens, Sjoerd; Blanco Sequeiros, Roberto; Komar, Gaber; Pollari, Mika; Eibisberger, Martin; Portugaller, Horst Rupert; Voglreiter, Philip; Flanagan, Ronan; Mariappan, Panchatcharam; Reinhardt, Martin.

In: European Radiology , 2019.

Research output: Contribution to journalArticleResearchpeer-review

Moche, M, Busse, H, Futterer, J, A Hinestrosa, C, Seider, D, Brandmaier, P, Kolesnik, M, Jenniskens, S, Blanco Sequeiros, R, Komar, G, Pollari, M, Eibisberger, M, Portugaller, HR, Voglreiter, P, Flanagan, R, Mariappan, P & Reinhardt, M 2019, 'Clinical evaluation of in silico planning and real-time simulation of hepatic radiofrequency ablation (ClinicIMPPACT Trial)' European Radiology . https://doi.org/10.1007/s00330-019-06411-5
Moche, Michael ; Busse, Harald ; Futterer, Jurgen ; A Hinestrosa, Camila ; Seider, Daniel ; Brandmaier, Philipp ; Kolesnik, Marina ; Jenniskens, Sjoerd ; Blanco Sequeiros, Roberto ; Komar, Gaber ; Pollari, Mika ; Eibisberger, Martin ; Portugaller, Horst Rupert ; Voglreiter, Philip ; Flanagan, Ronan ; Mariappan, Panchatcharam ; Reinhardt, Martin. / Clinical evaluation of in silico planning and real-time simulation of hepatic radiofrequency ablation (ClinicIMPPACT Trial). In: European Radiology . 2019.
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abstract = "ObjectivesTo evaluate the accuracy and clinical integrability of a comprehensive simulation tool to plan and predict radiofrequency ablation (RFA) zones in liver tumors.MethodsForty-five patients with 51 malignant hepatic lesions of different origins were included in a prospective multicenter trial. Prior to CT-guided RFA, all patients underwent multiphase CT which included acquisitions for the assessment of liver perfusion. These data were used to generate a 3D model of the liver. The intra-procedural position of the RFA probe was determined by CT and semi-automatically registered to the 3D model. Size and shape of the simulated ablation zones were compared with those of the thermal ablation zones segmented in contrast-enhanced CT images 1 month after RFA; procedure time was compared with a historical control group …",
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AU - Moche, Michael

AU - Busse, Harald

AU - Futterer, Jurgen

AU - A Hinestrosa, Camila

AU - Seider, Daniel

AU - Brandmaier, Philipp

AU - Kolesnik, Marina

AU - Jenniskens, Sjoerd

AU - Blanco Sequeiros, Roberto

AU - Komar, Gaber

AU - Pollari, Mika

AU - Eibisberger, Martin

AU - Portugaller, Horst Rupert

AU - Voglreiter, Philip

AU - Flanagan, Ronan

AU - Mariappan, Panchatcharam

AU - Reinhardt, Martin

PY - 2019

Y1 - 2019

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AB - ObjectivesTo evaluate the accuracy and clinical integrability of a comprehensive simulation tool to plan and predict radiofrequency ablation (RFA) zones in liver tumors.MethodsForty-five patients with 51 malignant hepatic lesions of different origins were included in a prospective multicenter trial. Prior to CT-guided RFA, all patients underwent multiphase CT which included acquisitions for the assessment of liver perfusion. These data were used to generate a 3D model of the liver. The intra-procedural position of the RFA probe was determined by CT and semi-automatically registered to the 3D model. Size and shape of the simulated ablation zones were compared with those of the thermal ablation zones segmented in contrast-enhanced CT images 1 month after RFA; procedure time was compared with a historical control group …

U2 - 10.1007/s00330-019-06411-5

DO - 10.1007/s00330-019-06411-5

M3 - Article

JO - European Radiology

JF - European Radiology

SN - 0938-7994

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