Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime

Melissa Horvat; Victoria Weilch; Robert Rädisch; Sebastian Hecko; Astrid Schiefer; Florian Rudroff; Birgit Wilding; Norbert Klempier; Miroslav Patek; Ludmila Martínková; Margit Winkler

doi:10.1039/D1CY01694F

Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime

Melissa Horvat, Victoria Weilch, Robert Rädisch, Sebastian Hecko, Astrid Schiefer, Florian Rudroff, Birgit Wilding, Norbert Klempier, Miroslav Patek, Ludmila Martínková, Margit Winkler^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

We report a new chemoenzymatic cascade starting with aldehyde synthesis by carboxylic acid reductase (CAR) followed by chemical in situ oxime formation. The final step to the nitrile is catalyzed by aldoxime dehydratase (Oxd). Full conversions of phenylacetic acid and hexanoic acid were achieved in a two-phase mode.

Original language	English
Pages (from-to)	62-66
Number of pages	5
Journal	Catalysis Science & Technology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1039/D1CY01694F
Publication status	Published - 7 Jan 2022

ASJC Scopus subject areas

Catalysis

Fields of Expertise

Human- & Biotechnology

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10.1039/D1CY01694FLicence: CC BY 4.0

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abstract = "We report a new chemoenzymatic cascade starting with aldehyde synthesis by carboxylic acid reductase (CAR) followed by chemical in situ oxime formation. The final step to the nitrile is catalyzed by aldoxime dehydratase (Oxd). Full conversions of phenylacetic acid and hexanoic acid were achieved in a two-phase mode.",

author = "Melissa Horvat and Victoria Weilch and Robert R{\"a}disch and Sebastian Hecko and Astrid Schiefer and Florian Rudroff and Birgit Wilding and Norbert Klempier and Miroslav Patek and Ludmila Mart{\'i}nkov{\'a} and Margit Winkler",

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language = "English",

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AU - Horvat, Melissa

AU - Weilch, Victoria

AU - Rädisch, Robert

AU - Hecko, Sebastian

AU - Schiefer, Astrid

AU - Rudroff, Florian

AU - Wilding, Birgit

AU - Klempier, Norbert

AU - Patek, Miroslav

AU - Martínková, Ludmila

AU - Winkler, Margit

PY - 2022/1/7

Y1 - 2022/1/7

N2 - We report a new chemoenzymatic cascade starting with aldehyde synthesis by carboxylic acid reductase (CAR) followed by chemical in situ oxime formation. The final step to the nitrile is catalyzed by aldoxime dehydratase (Oxd). Full conversions of phenylacetic acid and hexanoic acid were achieved in a two-phase mode.

AB - We report a new chemoenzymatic cascade starting with aldehyde synthesis by carboxylic acid reductase (CAR) followed by chemical in situ oxime formation. The final step to the nitrile is catalyzed by aldoxime dehydratase (Oxd). Full conversions of phenylacetic acid and hexanoic acid were achieved in a two-phase mode.

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U2 - 10.1039/D1CY01694F

DO - 10.1039/D1CY01694F

M3 - Article

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VL - 12

SP - 62

EP - 66

JO - Catalysis Science & Technology

JF - Catalysis Science & Technology

IS - 1

ER -

Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime

Abstract

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FWF - Nitriles - A new chemoenzymatic route from carboxylic acids to nitriles

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Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime

Abstract

ASJC Scopus subject areas

Fields of Expertise

Access to Document

Other files and links

Fingerprint

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FWF - Nitriles - A new chemoenzymatic route from carboxylic acids to nitriles

Cite this