CHAPTER 14: Microfluidic Systems and Optical Oxygen Sensors: A Perfect Match for Advancing Bioprocessing and Microbiology

Birgit Ungerböck, Torsten Mayr

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Abstract

Microfluidic devices provide intriguing tools for biology, biotechnology and life science. The small size with volumes in the L to fL scale and the fine control over the microenvironment offer an opportunity to accelerate research and development in these areas, where oxygen is a key parameter. Quantification of oxygen is therefore essential and optical sensors are ideally suited for this task because they can be downsized and easily integrated into microscale devices. The integrated oxygen-sensitive material can be read-out contactless with light through the channel wall. This chapter represents an overview of the integration and application of optical oxygen sensors into microfluidic devices and microreactors. It introduces microfluidics for biological systems and flags the necessity of oxygen monitoring. Challenges of integration and demands on optical sensor materials and detection systems are discussed. Sensor formats, integration methods and detection principles are reviewed. Microfluidic systems with integrated sensors are categorized by their application in microbioreactors, cell culture and tissue engineering and representative examples are showcased.

Original languageEnglish
Title of host publicationQuenched-phosphorescence Detection of Molecular Oxygen
Subtitle of host publicationApplications in Life Sciences
PublisherRoyal Society of Chemistry
Pages278-297
Number of pages20
Edition11
DOIs
Publication statusPublished - 1 Jan 2018

Publication series

NameRSC Detection Science
Number11
Volume2018-January
ISSN (Print)2052-3068
ISSN (Electronic)2052-3076

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ASJC Scopus subject areas

  • Bioengineering
  • Pathology and Forensic Medicine
  • Chemistry(all)
  • Environmental Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pollution
  • Biochemistry, medical

Cite this

Ungerböck, B., & Mayr, T. (2018). CHAPTER 14: Microfluidic Systems and Optical Oxygen Sensors: A Perfect Match for Advancing Bioprocessing and Microbiology. In Quenched-phosphorescence Detection of Molecular Oxygen: Applications in Life Sciences (11 ed., pp. 278-297). (RSC Detection Science; Vol. 2018-January, No. 11). Royal Society of Chemistry. https://doi.org/10.1039/9781788013451-00278