Abstract

MOFs have demonstrated outstanding properties for the protectionand controlled release of different bio-entities, from proteins toliving cells. Carbohydrates, as pure molecules or as a component ofproteins and cells, perform essential biological functions. Thus, anunderstanding of the role of carbohydrates in the formationof MOF-based bio-composites will facilitate their application tobiotechnology and medicine. Here, we investigate the role ofcarbohydrate molecular weight and chemical functionalization inthe formation of carbohydrate@MOF composites. We find thatchemical functionalization, such as carboxylation, that leads to anenhancement of metal cation concentration at the surface of themolecule triggers the rapid self-assembly of the MOF material,zeolitic-imidazolate framework 8 (ZIF-8). Furthermore, we determinethe encapsulation efficiency and measure the release properties ofthe carbohydrate under controlled conditions. Our findings showthat MOFs can be used to prepare a new class of biocomposites forthe delivery of carbohydrate-based therapeutics.
Original languageEnglish
Pages (from-to)969-977
Number of pages9
JournalMaterials Horizons
Volume6
Issue number5
Early online date20 Feb 2019
DOIs
Publication statusPublished - 1 Jun 2019

ASJC Scopus subject areas

  • Materials Science(all)

Fields of Expertise

  • Advanced Materials Science

Treatment code (Nähere Zuordnung)

  • Basic - Fundamental (Grundlagenforschung)

Cite this

Carbohydrates@MOFs. / Astria, Efwita; Thonhofer, Martin Simon; Ricco, Raffaele; Liang, Weibin; Angela, Chemelli; Tarzia, Andrew; Alt, Karen; Hagemeyer, Christoph; Rattenberger, Johannes; Schröttner, Hartmuth; Wrodnigg, Tanja Maria ; Amenitsch, Heinz; Huang, David; Doonan, Christian; Falcaro, Paolo.

In: Materials Horizons, Vol. 6, No. 5, 01.06.2019, p. 969-977.

Research output: Contribution to journalArticleResearchpeer-review

Astria, E, Thonhofer, MS, Ricco, R, Liang, W, Angela, C, Tarzia, A, Alt, K, Hagemeyer, C, Rattenberger, J, Schröttner, H, Wrodnigg, TM, Amenitsch, H, Huang, D, Doonan, C & Falcaro, P 2019, 'Carbohydrates@MOFs' Materials Horizons, vol. 6, no. 5, pp. 969-977. https://doi.org/10.1039/c8mh01611a
Astria E, Thonhofer MS, Ricco R, Liang W, Angela C, Tarzia A et al. Carbohydrates@MOFs. Materials Horizons. 2019 Jun 1;6(5):969-977. https://doi.org/10.1039/c8mh01611a
Astria, Efwita ; Thonhofer, Martin Simon ; Ricco, Raffaele ; Liang, Weibin ; Angela, Chemelli ; Tarzia, Andrew ; Alt, Karen ; Hagemeyer, Christoph ; Rattenberger, Johannes ; Schröttner, Hartmuth ; Wrodnigg, Tanja Maria ; Amenitsch, Heinz ; Huang, David ; Doonan, Christian ; Falcaro, Paolo. / Carbohydrates@MOFs. In: Materials Horizons. 2019 ; Vol. 6, No. 5. pp. 969-977.
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