C-5a-substituted validamine type glycosidase inhibitors.

Michael Schalli; Andreas Wolfsgruber; Andres Gonzalez Santana; Christina Tysoe; Roland Fischer; Arnold Stütz; Martin Thonhofer; Stephen G. Withers

doi:10.1016/j.carres.2017.01.006

C-5a-substituted validamine type glycosidase inhibitors.

Michael Schalli, Andreas Wolfsgruber, Andres Gonzalez Santana, Christina Tysoe, Roland Fischer, Arnold Stütz, Martin Thonhofer, Stephen G. Withers

Research output: Contribution to journal › Article › peer-review

Abstract

A series of N-alkyl derivatives of the D-galactosidase inhibitor 1,4-di-epi-validamine featuring lipophilic substituents at position C-5a was prepared and screened for their glycosidase inhibitory properties. Products turned out selective for β-galactosidases as well as β-glucosidases.

Original language	English
Pages (from-to)	1-9
Number of pages	9
Journal	Carbohydrate Research
Volume	440-441
DOIs	https://doi.org/10.1016/j.carres.2017.01.006
Publication status	Published - 2017

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@article{8afec6d2fdf04f6f97d430760db5b104,

title = "C-5a-substituted validamine type glycosidase inhibitors.",

abstract = "A series of N-alkyl derivatives of the D-galactosidase inhibitor 1,4-di-epi-validamine featuring lipophilic substituents at position C-5a was prepared and screened for their glycosidase inhibitory properties. Products turned out selective for β-galactosidases as well as β-glucosidases.",

keywords = "aminodeoxy oligosaccharide prepn glucosidase galactosidase inhibitor validamine glycosidase",

author = "Michael Schalli and Andreas Wolfsgruber and {Gonzalez Santana}, Andres and Christina Tysoe and Roland Fischer and Arnold St{\"u}tz and Martin Thonhofer and Withers, {Stephen G.}",

year = "2017",

doi = "10.1016/j.carres.2017.01.006",

language = "English",

volume = "440-441",

pages = "1--9",

journal = "Carbohydrate Research",

issn = "0008-6215",

publisher = "Elsevier Ltd.",

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TY - JOUR

T1 - C-5a-substituted validamine type glycosidase inhibitors.

AU - Schalli, Michael

AU - Wolfsgruber, Andreas

AU - Gonzalez Santana, Andres

AU - Tysoe, Christina

AU - Fischer, Roland

AU - Stütz, Arnold

AU - Thonhofer, Martin

AU - Withers, Stephen G.

PY - 2017

Y1 - 2017

N2 - A series of N-alkyl derivatives of the D-galactosidase inhibitor 1,4-di-epi-validamine featuring lipophilic substituents at position C-5a was prepared and screened for their glycosidase inhibitory properties. Products turned out selective for β-galactosidases as well as β-glucosidases.

AB - A series of N-alkyl derivatives of the D-galactosidase inhibitor 1,4-di-epi-validamine featuring lipophilic substituents at position C-5a was prepared and screened for their glycosidase inhibitory properties. Products turned out selective for β-galactosidases as well as β-glucosidases.

KW - aminodeoxy oligosaccharide prepn glucosidase galactosidase inhibitor validamine glycosidase

U2 - 10.1016/j.carres.2017.01.006

DO - 10.1016/j.carres.2017.01.006

M3 - Article

VL - 440-441

SP - 1

EP - 9

JO - Carbohydrate Research

JF - Carbohydrate Research

SN - 0008-6215

ER -

C-5a-substituted validamine type glycosidase inhibitors.

Abstract

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