C-5a-substituted validamine type glycosidase inhibitors.

Michael Schalli, Andreas Wolfsgruber, Andres Gonzalez Santana, Christina Tysoe, Roland Fischer, Arnold Stütz, Martin Thonhofer, Stephen G. Withers

Research output: Contribution to journal › Article › Research › peer-review

Abstract

A series of N-alkyl derivs. of the D-galactosidase inhibitor 1,4-di-epi-validamine featuring lipophilic substituents at position C-5a was prepd. and screened for their glycosidase inhibitory properties. Products turned out selective for β-galactosidases as well as β-glucosidases. [on SciFinder(R)]
LanguageEnglish
Pages1-9
Number of pages9
JournalCarbohydrate research
Volume440-441
DOIs
StatusPublished - 2017

Keywords

    Cite this

    C-5a-substituted validamine type glycosidase inhibitors. / Schalli, Michael; Wolfsgruber, Andreas; Gonzalez Santana, Andres; Tysoe, Christina; Fischer, Roland; Stütz, Arnold; Thonhofer, Martin; Withers, Stephen G.

    In: Carbohydrate research, Vol. 440-441, 2017, p. 1-9.

    Research output: Contribution to journal › Article › Research › peer-review

    Schalli, M, Wolfsgruber, A, Gonzalez Santana, A, Tysoe, C, Fischer, R, Stütz, A, Thonhofer, M & Withers, SG 2017, 'C-5a-substituted validamine type glycosidase inhibitors.' Carbohydrate research, vol. 440-441, pp. 1-9. DOI: 10.1016/j.carres.2017.01.006
    Schalli M, Wolfsgruber A, Gonzalez Santana A, Tysoe C, Fischer R, Stütz A et al. C-5a-substituted validamine type glycosidase inhibitors. Carbohydrate research. 2017;440-441:1-9. Available from, DOI: 10.1016/j.carres.2017.01.006
    Schalli, Michael ; Wolfsgruber, Andreas ; Gonzalez Santana, Andres ; Tysoe, Christina ; Fischer, Roland ; Stütz, Arnold ; Thonhofer, Martin ; Withers, Stephen G./ C-5a-substituted validamine type glycosidase inhibitors.In: Carbohydrate research. 2017 ; Vol. 440-441. pp. 1-9
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    AU - Tysoe,Christina

    AU - Fischer,Roland

    AU - Stütz,Arnold

    AU - Thonhofer,Martin

    AU - Withers,Stephen G.

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    AB - A series of N-alkyl derivs. of the D-galactosidase inhibitor 1,4-di-epi-validamine featuring lipophilic substituents at position C-5a was prepd. and screened for their glycosidase inhibitory properties. Products turned out selective for β-galactosidases as well as β-glucosidases. [on SciFinder(R)]

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