C-5a-substituted validamine type glycosidase inhibitors.

Michael Schalli, Andreas Wolfsgruber, Andres Gonzalez Santana, Christina Tysoe, Roland Fischer, Arnold Stütz, Martin Thonhofer, Stephen G. Withers

Research output: Contribution to journalArticleResearchpeer-review

Abstract

A series of N-alkyl derivs. of the D-galactosidase inhibitor 1,4-di-epi-validamine featuring lipophilic substituents at position C-5a was prepd. and screened for their glycosidase inhibitory properties. Products turned out selective for β-galactosidases as well as β-glucosidases. [on SciFinder(R)]
Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalCarbohydrate Research
Volume440-441
DOIs
Publication statusPublished - 2017

Keywords

    Cite this

    C-5a-substituted validamine type glycosidase inhibitors. / Schalli, Michael; Wolfsgruber, Andreas; Gonzalez Santana, Andres; Tysoe, Christina; Fischer, Roland; Stütz, Arnold; Thonhofer, Martin; Withers, Stephen G.

    In: Carbohydrate Research, Vol. 440-441, 2017, p. 1-9.

    Research output: Contribution to journalArticleResearchpeer-review

    Schalli, Michael ; Wolfsgruber, Andreas ; Gonzalez Santana, Andres ; Tysoe, Christina ; Fischer, Roland ; Stütz, Arnold ; Thonhofer, Martin ; Withers, Stephen G. / C-5a-substituted validamine type glycosidase inhibitors. In: Carbohydrate Research. 2017 ; Vol. 440-441. pp. 1-9.
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    AU - Gonzalez Santana, Andres

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    AU - Fischer, Roland

    AU - Stütz, Arnold

    AU - Thonhofer, Martin

    AU - Withers, Stephen G.

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    KW - aminodeoxy oligosaccharide prepn glucosidase galactosidase inhibitor validamine glycosidase

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