Biomechanical relevance of the microstructure in artery walls with a focus on passive and active components

Gerhard A Holzapfel, Ray W Ogden

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The microstructure of arteries, consisting, in particular, of collagen, elastin, and vascular smooth muscle cells, plays a very significant role in their biomechanical response during a cardiac cycle. In this article, we highlight the microstructure and the contributions of each of its components to the overall mechanical behavior. We also describe the changes of the microstructure that occur as a result of abdominal aortic aneurysms and disease, such as atherosclerosis. We also focus on how the passive and active constituents are incorporated into a mathematical model without going into detail of the mathematical formulation. We conclude by mentioning open problems toward a better characterization of the biomechanical aspects of arteries that will be beneficial for a better understanding of cardiovascular pathophysiology.

Original languageEnglish
Pages (from-to)H540-H549
JournalAmerican Journal of Physiology / Heart and Circulatory Physiology
Volume315
Issue number3
DOIs
Publication statusPublished - 1 Sep 2018

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Arteries
Aortic Diseases
Elastin
Abdominal Aortic Aneurysm
Vascular Smooth Muscle
Smooth Muscle Myocytes
Atherosclerosis
Theoretical Models
Collagen

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Biomechanical relevance of the microstructure in artery walls with a focus on passive and active components. / Holzapfel, Gerhard A; Ogden, Ray W.

In: American Journal of Physiology / Heart and Circulatory Physiology, Vol. 315, No. 3, 01.09.2018, p. H540-H549.

Research output: Contribution to journalArticleResearchpeer-review

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