Abstract
Oxidation chemistry using enzymes is approaching maturity and practical applicability in organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists to perform highly selective and efficient transformations ranging from simple alcohol oxidations to stereoselective halogenations of non-activated C-H-bonds. For many of these reactions no 'classical' chemical counterpart is known. Hence oxidoreductases open up shorter synthesis routes via more direct access to the target products. The generally very mild reaction conditions may also reduce the environmental impact of biocatalytic reactions compared to classical counterparts. This contribution critically summarises the most important current developments in the field of biocatalytic oxidation chemistry, identifies the most pressing bottlenecks as well as promising solutions.
| Original language | English |
|---|---|
| Pages (from-to) | 9238-9261 |
| Journal | Angewandte Chemie / International Edition |
| Volume | 57 |
| Issue number | 30 |
| DOIs | |
| Publication status | Published - Jul 2018 |
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Keywords
- Journal Article
Cite this
Biocatalytic oxidation reactions - a Chemist's perspective. / Dong, JiaJia; Fernández-Fueyo, Elena; Hollmann, Frank; Paul, Caroline; Pasic, Milja; Schmidt, Sandy; Wang, Yonghua; Younes, Sabry; Zhang, Wuyuan.
In: Angewandte Chemie / International Edition , Vol. 57, No. 30, 07.2018, p. 9238-9261.Research output: Contribution to journal › Article › Research › peer-review
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TY - JOUR
T1 - Biocatalytic oxidation reactions - a Chemist's perspective
AU - Dong, JiaJia
AU - Fernández-Fueyo, Elena
AU - Hollmann, Frank
AU - Paul, Caroline
AU - Pasic, Milja
AU - Schmidt, Sandy
AU - Wang, Yonghua
AU - Younes, Sabry
AU - Zhang, Wuyuan
N1 - © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2018/7
Y1 - 2018/7
N2 - Oxidation chemistry using enzymes is approaching maturity and practical applicability in organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists to perform highly selective and efficient transformations ranging from simple alcohol oxidations to stereoselective halogenations of non-activated C-H-bonds. For many of these reactions no 'classical' chemical counterpart is known. Hence oxidoreductases open up shorter synthesis routes via more direct access to the target products. The generally very mild reaction conditions may also reduce the environmental impact of biocatalytic reactions compared to classical counterparts. This contribution critically summarises the most important current developments in the field of biocatalytic oxidation chemistry, identifies the most pressing bottlenecks as well as promising solutions.
AB - Oxidation chemistry using enzymes is approaching maturity and practical applicability in organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists to perform highly selective and efficient transformations ranging from simple alcohol oxidations to stereoselective halogenations of non-activated C-H-bonds. For many of these reactions no 'classical' chemical counterpart is known. Hence oxidoreductases open up shorter synthesis routes via more direct access to the target products. The generally very mild reaction conditions may also reduce the environmental impact of biocatalytic reactions compared to classical counterparts. This contribution critically summarises the most important current developments in the field of biocatalytic oxidation chemistry, identifies the most pressing bottlenecks as well as promising solutions.
KW - Journal Article
U2 - 10.1002/anie.201800343
DO - 10.1002/anie.201800343
M3 - Article
VL - 57
SP - 9238
EP - 9261
JO - Angewandte Chemie / International Edition
JF - Angewandte Chemie / International Edition
SN - 1433-7851
IS - 30
ER -