Biocatalytic oxidation reactions - a Chemist's perspective

JiaJia Dong, Elena Fernández-Fueyo, Frank Hollmann, Caroline Paul, Milja Pasic, Sandy Schmidt, Yonghua Wang, Sabry Younes, Wuyuan Zhang

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Oxidation chemistry using enzymes is approaching maturity and practical applicability in organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists to perform highly selective and efficient transformations ranging from simple alcohol oxidations to stereoselective halogenations of non-activated C-H-bonds. For many of these reactions no 'classical' chemical counterpart is known. Hence oxidoreductases open up shorter synthesis routes via more direct access to the target products. The generally very mild reaction conditions may also reduce the environmental impact of biocatalytic reactions compared to classical counterparts. This contribution critically summarises the most important current developments in the field of biocatalytic oxidation chemistry, identifies the most pressing bottlenecks as well as promising solutions.

Original languageEnglish
Pages (from-to)9238-9261
JournalAngewandte Chemie / International Edition
Volume57
Issue number30
DOIs
Publication statusPublished - Jul 2018

Fingerprint

Oxidation
Oxidoreductases
Enzymes
Halogenation
Redox reactions
Environmental impact
Alcohols

Keywords

  • Journal Article

Cite this

Dong, J., Fernández-Fueyo, E., Hollmann, F., Paul, C., Pasic, M., Schmidt, S., ... Zhang, W. (2018). Biocatalytic oxidation reactions - a Chemist's perspective. Angewandte Chemie / International Edition , 57(30), 9238-9261. https://doi.org/10.1002/anie.201800343

Biocatalytic oxidation reactions - a Chemist's perspective. / Dong, JiaJia; Fernández-Fueyo, Elena; Hollmann, Frank; Paul, Caroline; Pasic, Milja; Schmidt, Sandy; Wang, Yonghua; Younes, Sabry; Zhang, Wuyuan.

In: Angewandte Chemie / International Edition , Vol. 57, No. 30, 07.2018, p. 9238-9261.

Research output: Contribution to journalArticleResearchpeer-review

Dong, J, Fernández-Fueyo, E, Hollmann, F, Paul, C, Pasic, M, Schmidt, S, Wang, Y, Younes, S & Zhang, W 2018, 'Biocatalytic oxidation reactions - a Chemist's perspective' Angewandte Chemie / International Edition , vol. 57, no. 30, pp. 9238-9261. https://doi.org/10.1002/anie.201800343
Dong, JiaJia ; Fernández-Fueyo, Elena ; Hollmann, Frank ; Paul, Caroline ; Pasic, Milja ; Schmidt, Sandy ; Wang, Yonghua ; Younes, Sabry ; Zhang, Wuyuan. / Biocatalytic oxidation reactions - a Chemist's perspective. In: Angewandte Chemie / International Edition . 2018 ; Vol. 57, No. 30. pp. 9238-9261.
@article{4f8b41e2c25f4c7ba66fa9c6690e9738,
title = "Biocatalytic oxidation reactions - a Chemist's perspective",
abstract = "Oxidation chemistry using enzymes is approaching maturity and practical applicability in organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists to perform highly selective and efficient transformations ranging from simple alcohol oxidations to stereoselective halogenations of non-activated C-H-bonds. For many of these reactions no 'classical' chemical counterpart is known. Hence oxidoreductases open up shorter synthesis routes via more direct access to the target products. The generally very mild reaction conditions may also reduce the environmental impact of biocatalytic reactions compared to classical counterparts. This contribution critically summarises the most important current developments in the field of biocatalytic oxidation chemistry, identifies the most pressing bottlenecks as well as promising solutions.",
keywords = "Journal Article",
author = "JiaJia Dong and Elena Fern{\'a}ndez-Fueyo and Frank Hollmann and Caroline Paul and Milja Pasic and Sandy Schmidt and Yonghua Wang and Sabry Younes and Wuyuan Zhang",
note = "{\circledC} 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",
year = "2018",
month = "7",
doi = "10.1002/anie.201800343",
language = "English",
volume = "57",
pages = "9238--9261",
journal = "Angewandte Chemie / International Edition",
issn = "1433-7851",
publisher = "Wiley-VCH",
number = "30",

}

TY - JOUR

T1 - Biocatalytic oxidation reactions - a Chemist's perspective

AU - Dong, JiaJia

AU - Fernández-Fueyo, Elena

AU - Hollmann, Frank

AU - Paul, Caroline

AU - Pasic, Milja

AU - Schmidt, Sandy

AU - Wang, Yonghua

AU - Younes, Sabry

AU - Zhang, Wuyuan

N1 - © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PY - 2018/7

Y1 - 2018/7

N2 - Oxidation chemistry using enzymes is approaching maturity and practical applicability in organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists to perform highly selective and efficient transformations ranging from simple alcohol oxidations to stereoselective halogenations of non-activated C-H-bonds. For many of these reactions no 'classical' chemical counterpart is known. Hence oxidoreductases open up shorter synthesis routes via more direct access to the target products. The generally very mild reaction conditions may also reduce the environmental impact of biocatalytic reactions compared to classical counterparts. This contribution critically summarises the most important current developments in the field of biocatalytic oxidation chemistry, identifies the most pressing bottlenecks as well as promising solutions.

AB - Oxidation chemistry using enzymes is approaching maturity and practical applicability in organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists to perform highly selective and efficient transformations ranging from simple alcohol oxidations to stereoselective halogenations of non-activated C-H-bonds. For many of these reactions no 'classical' chemical counterpart is known. Hence oxidoreductases open up shorter synthesis routes via more direct access to the target products. The generally very mild reaction conditions may also reduce the environmental impact of biocatalytic reactions compared to classical counterparts. This contribution critically summarises the most important current developments in the field of biocatalytic oxidation chemistry, identifies the most pressing bottlenecks as well as promising solutions.

KW - Journal Article

U2 - 10.1002/anie.201800343

DO - 10.1002/anie.201800343

M3 - Article

VL - 57

SP - 9238

EP - 9261

JO - Angewandte Chemie / International Edition

JF - Angewandte Chemie / International Edition

SN - 1433-7851

IS - 30

ER -