Biocatalytic oxidation reactions - a Chemist's perspective

JiaJia Dong, Elena Fernández-Fueyo, Frank Hollmann, Caroline Paul, Milja Pasic, Sandy Schmidt, Yonghua Wang, Sabry Younes, Wuyuan Zhang

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Oxidation chemistry using enzymes is approaching maturity and practical applicability in organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists to perform highly selective and efficient transformations ranging from simple alcohol oxidations to stereoselective halogenations of non-activated C-H-bonds. For many of these reactions no 'classical' chemical counterpart is known. Hence oxidoreductases open up shorter synthesis routes via more direct access to the target products. The generally very mild reaction conditions may also reduce the environmental impact of biocatalytic reactions compared to classical counterparts. This contribution critically summarises the most important current developments in the field of biocatalytic oxidation chemistry, identifies the most pressing bottlenecks as well as promising solutions.

LanguageEnglish
Pages9238-9261
JournalAngewandte Chemie (Weinheim) / International edition in English
Volume57
Issue number30
DOIs
StatusPublished - Jul 2018

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Oxidation
Oxidoreductases
Enzymes
Halogenation
Redox reactions
Environmental impact
Alcohols

Keywords

  • Journal Article

Cite this

Dong, J., Fernández-Fueyo, E., Hollmann, F., Paul, C., Pasic, M., Schmidt, S., ... Zhang, W. (2018). Biocatalytic oxidation reactions - a Chemist's perspective. Angewandte Chemie (Weinheim) / International edition in English, 57(30), 9238-9261. DOI: 10.1002/anie.201800343

Biocatalytic oxidation reactions - a Chemist's perspective. / Dong, JiaJia; Fernández-Fueyo, Elena; Hollmann, Frank; Paul, Caroline; Pasic, Milja; Schmidt, Sandy; Wang, Yonghua; Younes, Sabry; Zhang, Wuyuan.

In: Angewandte Chemie (Weinheim) / International edition in English, Vol. 57, No. 30, 07.2018, p. 9238-9261.

Research output: Contribution to journalArticleResearchpeer-review

Dong, J, Fernández-Fueyo, E, Hollmann, F, Paul, C, Pasic, M, Schmidt, S, Wang, Y, Younes, S & Zhang, W 2018, 'Biocatalytic oxidation reactions - a Chemist's perspective' Angewandte Chemie (Weinheim) / International edition in English, vol. 57, no. 30, pp. 9238-9261. DOI: 10.1002/anie.201800343
Dong J, Fernández-Fueyo E, Hollmann F, Paul C, Pasic M, Schmidt S et al. Biocatalytic oxidation reactions - a Chemist's perspective. Angewandte Chemie (Weinheim) / International edition in English. 2018 Jul;57(30):9238-9261. Available from, DOI: 10.1002/anie.201800343
Dong, JiaJia ; Fernández-Fueyo, Elena ; Hollmann, Frank ; Paul, Caroline ; Pasic, Milja ; Schmidt, Sandy ; Wang, Yonghua ; Younes, Sabry ; Zhang, Wuyuan. / Biocatalytic oxidation reactions - a Chemist's perspective. In: Angewandte Chemie (Weinheim) / International edition in English. 2018 ; Vol. 57, No. 30. pp. 9238-9261
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