Biocatalytic carboxylate reduction – recent advances and new enzymes

Margit Winkler*, Jonathan Guyang Ling

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Carboxylate reductases (CARs) are valuable catalysts for the selective one-step reduction of carboxylic acids to their corresponding aldehydes. In recent years, numerous new CARs have been made available, studied and applied in the context of biocatalytic syntheses. The preparation of aldehydes as end products for the flavor and fragrance sector and the integration of CARs in cascade reactions with aldehydes as the key intermediates represent the two major fields of applications. This review gives a comprehensive overview of the current toolbox of recombinant CARs and their numerous carboxylate substrates. Non-natural functions of CARs are highlighted and recent insight into the structure-function relationship of CARs are summarized.
Original languageEnglish
Article numbere202200441
Issue number19
Publication statusPublished - 2022


  • aldehyde
  • ATR enzyme
  • carboxylic acid reductase
  • NRPS
  • substrate scope

ASJC Scopus subject areas

  • Catalysis
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fields of Expertise

  • Human- & Biotechnology


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