Bioactive MIL-88A Framework Hollow Spheres via Interfacial Reaction In-Droplet Microfluidics for Enzyme and Nanoparticle Encapsulation

Guan Young Jeong, Raffaele Ricco, Kang Liang, Johanna Ludwig, Jin Oh Kim, Paolo Falcaro, Dong Pyo Kim

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Functional bio-MOF hollow spheres with controlled size in the 35-2000 μm range were successfully synthesized by interfacial reaction using a continuous-flow droplet microfluidic system in a single step and one-flow strategy. The architecture of MIL-88A frameworks was extended from single-shell to double-shell hollow spheres. Moreover, various functional nanoparticles (silica, cobalt, and UiO-66(Zr) MOF) were directly encapsulated in the single-shell hollow spheres, while maintaining the functionality of the cargo. In particular, three kinds of enzymes (glycerol dehydrogenase, horseradish peroxidase, and acetylcholinesterase) were also encapsulated inside the single-shell hollow spheres under mild conditions. The catalytic activity and the superior recyclability of the encapsulated enzymes were demonstrated against free enzymes.

Original languageEnglish
Pages (from-to)7903-7909
Number of pages7
JournalChemistry of Materials
Volume27
Issue number23
DOIs
Publication statusPublished - 6 Nov 2015
Externally publishedYes

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Surface chemistry
Encapsulation
Microfluidics
Enzymes
Nanoparticles
glycerol dehydrogenase
Horseradish Peroxidase
Acetylcholinesterase
Cobalt
Glycerol
Silicon Dioxide
Catalyst activity
Silica
N(1)-methyl-2-lysergic acid diethylamide

ASJC Scopus subject areas

  • Materials Chemistry
  • Chemical Engineering(all)
  • Chemistry(all)

Cite this

Bioactive MIL-88A Framework Hollow Spheres via Interfacial Reaction In-Droplet Microfluidics for Enzyme and Nanoparticle Encapsulation. / Jeong, Guan Young; Ricco, Raffaele; Liang, Kang; Ludwig, Johanna; Kim, Jin Oh; Falcaro, Paolo; Kim, Dong Pyo.

In: Chemistry of Materials, Vol. 27, No. 23, 06.11.2015, p. 7903-7909.

Research output: Contribution to journalArticleResearchpeer-review

Jeong, Guan Young ; Ricco, Raffaele ; Liang, Kang ; Ludwig, Johanna ; Kim, Jin Oh ; Falcaro, Paolo ; Kim, Dong Pyo. / Bioactive MIL-88A Framework Hollow Spheres via Interfacial Reaction In-Droplet Microfluidics for Enzyme and Nanoparticle Encapsulation. In: Chemistry of Materials. 2015 ; Vol. 27, No. 23. pp. 7903-7909.
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