Bioactive MIL-88A Framework Hollow Spheres via Interfacial Reaction In-Droplet Microfluidics for Enzyme and Nanoparticle Encapsulation

Guan Young Jeong; Raffaele Ricco; Kang Liang; Johanna Ludwig; Jin Oh Kim; Paolo Falcaro; Dong Pyo Kim

doi:10.1021/acs.chemmater.5b02847

Bioactive MIL-88A Framework Hollow Spheres via Interfacial Reaction In-Droplet Microfluidics for Enzyme and Nanoparticle Encapsulation

Guan Young Jeong, Raffaele Ricco, Kang Liang, Johanna Ludwig, Jin Oh Kim, Paolo Falcaro^*, Dong Pyo Kim

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Functional bio-MOF hollow spheres with controlled size in the 35-2000 μm range were successfully synthesized by interfacial reaction using a continuous-flow droplet microfluidic system in a single step and one-flow strategy. The architecture of MIL-88A frameworks was extended from single-shell to double-shell hollow spheres. Moreover, various functional nanoparticles (silica, cobalt, and UiO-66(Zr) MOF) were directly encapsulated in the single-shell hollow spheres, while maintaining the functionality of the cargo. In particular, three kinds of enzymes (glycerol dehydrogenase, horseradish peroxidase, and acetylcholinesterase) were also encapsulated inside the single-shell hollow spheres under mild conditions. The catalytic activity and the superior recyclability of the encapsulated enzymes were demonstrated against free enzymes.

Original language	English
Pages (from-to)	7903-7909
Number of pages	7
Journal	Chemistry of Materials
Volume	27
Issue number	23
DOIs	https://doi.org/10.1021/acs.chemmater.5b02847
Publication status	Published - 6 Nov 2015
Externally published	Yes

ASJC Scopus subject areas

Materials Chemistry
Chemical Engineering(all)
Chemistry(all)

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10.1021/acs.chemmater.5b02847

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title = "Bioactive MIL-88A Framework Hollow Spheres via Interfacial Reaction In-Droplet Microfluidics for Enzyme and Nanoparticle Encapsulation",

abstract = "Functional bio-MOF hollow spheres with controlled size in the 35-2000 μm range were successfully synthesized by interfacial reaction using a continuous-flow droplet microfluidic system in a single step and one-flow strategy. The architecture of MIL-88A frameworks was extended from single-shell to double-shell hollow spheres. Moreover, various functional nanoparticles (silica, cobalt, and UiO-66(Zr) MOF) were directly encapsulated in the single-shell hollow spheres, while maintaining the functionality of the cargo. In particular, three kinds of enzymes (glycerol dehydrogenase, horseradish peroxidase, and acetylcholinesterase) were also encapsulated inside the single-shell hollow spheres under mild conditions. The catalytic activity and the superior recyclability of the encapsulated enzymes were demonstrated against free enzymes.",

author = "Jeong, {Guan Young} and Raffaele Ricco and Kang Liang and Johanna Ludwig and Kim, {Jin Oh} and Paolo Falcaro and Kim, {Dong Pyo}",

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doi = "10.1021/acs.chemmater.5b02847",

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AU - Jeong, Guan Young

AU - Ricco, Raffaele

AU - Liang, Kang

AU - Ludwig, Johanna

AU - Kim, Jin Oh

AU - Falcaro, Paolo

AU - Kim, Dong Pyo

PY - 2015/11/6

Y1 - 2015/11/6

N2 - Functional bio-MOF hollow spheres with controlled size in the 35-2000 μm range were successfully synthesized by interfacial reaction using a continuous-flow droplet microfluidic system in a single step and one-flow strategy. The architecture of MIL-88A frameworks was extended from single-shell to double-shell hollow spheres. Moreover, various functional nanoparticles (silica, cobalt, and UiO-66(Zr) MOF) were directly encapsulated in the single-shell hollow spheres, while maintaining the functionality of the cargo. In particular, three kinds of enzymes (glycerol dehydrogenase, horseradish peroxidase, and acetylcholinesterase) were also encapsulated inside the single-shell hollow spheres under mild conditions. The catalytic activity and the superior recyclability of the encapsulated enzymes were demonstrated against free enzymes.

AB - Functional bio-MOF hollow spheres with controlled size in the 35-2000 μm range were successfully synthesized by interfacial reaction using a continuous-flow droplet microfluidic system in a single step and one-flow strategy. The architecture of MIL-88A frameworks was extended from single-shell to double-shell hollow spheres. Moreover, various functional nanoparticles (silica, cobalt, and UiO-66(Zr) MOF) were directly encapsulated in the single-shell hollow spheres, while maintaining the functionality of the cargo. In particular, three kinds of enzymes (glycerol dehydrogenase, horseradish peroxidase, and acetylcholinesterase) were also encapsulated inside the single-shell hollow spheres under mild conditions. The catalytic activity and the superior recyclability of the encapsulated enzymes were demonstrated against free enzymes.

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Bioactive MIL-88A Framework Hollow Spheres via Interfacial Reaction In-Droplet Microfluidics for Enzyme and Nanoparticle Encapsulation

Abstract

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