Benzyl- and dibenzyl tetrahydropyridinylidene ammonium salts with antiplasmodial and antitrypanosomal activity

Werner Seebacher*, Marcel Kaiser, Pascal Maeser, Robert Saf, Eva-Maria Pferschy-Wenzig, Robert Weis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Several 1-benzyl and 1,3-dibenzyl derivatives of tetrahydropyridinylidene salts with differing electron withdrawing substituents at the aromatic residues have been prepared. In addition, the amine moiety in position 4 was varied. The new compounds were investigated for their antiplasmodial and antitrypanosomal activities as well as for their cytotoxicity. They were characterized using FT-IR, HRMS and NMR spectroscopy. Structure–activity relationships including reported compounds are discussed. Graphical abstract: [Figure not available: see fulltext.].

Original languageEnglish
Pages (from-to)105-114
Number of pages10
JournalMonatshefte fur Chemie
Volume154
Issue number1
Early online date20 Nov 2022
DOIs
Publication statusPublished - Jan 2023

Keywords

  • Antiprotozoal activity
  • Alkylations
  • Structure-activity relationships
  • Heterocycles
  • Drug research
  • Structure–activity relationships

ASJC Scopus subject areas

  • Chemistry(all)

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