Abstract
Several 1-benzyl and 1,3-dibenzyl derivatives of tetrahydropyridinylidene salts with differing electron withdrawing substituents at the aromatic residues have been prepared. In addition, the amine moiety in position 4 was varied. The new compounds were investigated for their antiplasmodial and antitrypanosomal activities as well as for their cytotoxicity. They were characterized using FT-IR, HRMS and NMR spectroscopy. Structure–activity relationships including reported compounds are discussed. Graphical abstract: [Figure not available: see fulltext.].
Original language | English |
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Pages (from-to) | 105-114 |
Number of pages | 10 |
Journal | Monatshefte fur Chemie |
Volume | 154 |
Issue number | 1 |
Early online date | 20 Nov 2022 |
DOIs | |
Publication status | Published - Jan 2023 |
Keywords
- Antiprotozoal activity
- Alkylations
- Structure-activity relationships
- Heterocycles
- Drug research
- Structure–activity relationships
ASJC Scopus subject areas
- Chemistry(all)