Abstract
Oral drug therapy is generally provided in the form of solid oral dosage forms (SODF) that have to be swallowed and move throughout the oro-esophageal system. Previous studies have provided evidence that the oro-esophageal transit of SODF depends on their shape, size, density, and surface characteristics. To estimate the impact of SODF surface coatings during esophageal transit, an in vitro system was implemented to investigate the gliding performance across an artificial mucous layer. In this work, formulations comprised of different slippery-inducing agents combined with a common film forming agent were evaluated using the artificial mucous layer system. Xanthan gum (XG) and polyethylene glycol 1500 (PEG) were applied as film-forming agents, while carnauba wax (CW), lecithin (LE), carrageenan (CA), gellan gum (GG) and sodium alginate (SA), and their combination with sodium lauryl sulfate (SLS), were applied as slippery-inducing components. All tested formulations presented lower static friction (SF) as compared to the negative control (uncoated disc, C, F0), whereas only CW/SLS-based formulations showed similar performance to F0 regarding dynamic friction (DF). The applied multivariate analysis approach allowed a higher level of detail to the evaluation and supported a better identification of excipients and respective concentrations that are predicted to improve in vivo swallowing safety.
Original language | English |
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Article number | 1241 |
Pages (from-to) | 1-10 |
Number of pages | 10 |
Journal | Pharmaceutics |
Volume | 12 |
Issue number | 12 |
DOIs | |
Publication status | Published - Dec 2020 |
Keywords
- Artificial mucous layer system
- Dynamic friction
- Film coating materials
- Oro-esophageal transit
- Predicted gliding performance
- Principal component analysis
- Solid oral dosage forms
- Static friction
- Swallowing safety
- Xanthan gum
ASJC Scopus subject areas
- Pharmaceutical Science