An approach for visualization of the interaction between collagen and elastin in loaded human aortic tissues

Anna Pukaluk*, Heimo Wolinski, Christian Viertler, Peter Regitnig, Gerhard Holzapfel, Gerhard Sommer

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference paperpeer-review

Abstract

Knowledge of the interaction between the constituents of loaded aortic tissues is crucial to expand our understanding of load-bearing mechanisms in the aorta. We have therefore developed a procedure that enables simultaneous multi-photon microscopy imaging of collagen and elastin in human aortic tissue during the biaxial extension test. The microscopy images obtained were verified with the results of the histological staining. The mechanical response was also compared with findings from previously performed biaxial extension tests. The proposed pipeline has shown successful and has great potential for structural analysis of human aortic tissue.
Original languageEnglish
Title of host publicationProceedings of the Annual Meeting of the Austrian Society for Biomedical Engineering ÖGBMT2021
EditorsGernot Müller-Putz, Christian Baumgartner
Place of PublicationGraz
PublisherVerlag der Technischen Universität Graz
Pages21-24
ISBN (Print)978-3-85125-826-4
DOIs
Publication statusPublished - 2021
EventAnnual Meeting of the Austrian Society for Biomedical Engineering ÖGBMT2021 - Graz, Austria
Duration: 30 Sep 20211 Oct 2021

Conference

ConferenceAnnual Meeting of the Austrian Society for Biomedical Engineering ÖGBMT2021
Country/TerritoryAustria
CityGraz
Period30/09/211/10/21

Keywords

  • human aorta
  • collagen
  • elastin
  • biaxial extension test
  • multi-photon microscopy

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