Alcohol Dehydrogenases Catalyze the Reduction of Thioesters

Sabry H.H. Younes, Yan Ni, Sandy Schmidt, Wolfgang Kroutil, Frank Hollmann*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review


    Alcohol dehydrogenases are well-established catalysts for various reduction reactions. However, the reduction of carboxylic acid derivatives has not yet been reported with these enzymes. In this contribution, we demonstrated that carboxylic acid thioesters could be readily reduced by a range of alcohol dehydrogenases, albeit at significantly reduced rates relative to those observed for corresponding ketones. A molecular explanation, especially for the lower turnover rates for thioesters relative to those obtained for ketones, is presented, as is a preliminary substrate scope.

    Original languageEnglish
    Pages (from-to)1389-1392
    Number of pages4
    Issue number8
    Publication statusPublished - 21 Apr 2017


    • alcohols
    • biocatalysis
    • enzymes
    • reduction
    • thioesters

    ASJC Scopus subject areas

    • Catalysis
    • Physical and Theoretical Chemistry
    • Organic Chemistry
    • Inorganic Chemistry


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