Advanced therapies of skin injuries

Tina Maver, Uroš Maver, Karin Stana Kleinschek, Irena Mlinaric-Rascan, Dragica Maja Smrke

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

The loss of tissue is still one of the most challenging problems in healthcare. Efficient laboratory expansion of skin tissue to reproduce the skins barrier function can make the difference between life and death for patients with extensive full-thickness burns, chronic wounds, or genetic disorders such as bullous conditions. This engineering has been initiated based on the acute need in the 1980s and today, tissue-engineered skin is the reality. The human skin equivalents are available not only as models for permeation and toxicity screening, but are frequently applied in vivo as clinical skin substitutes. This review aims to introduce the most important recent development in the extensive field of tissue engineering and to describe already approved, commercially available skin substitutes in clinical use.

Original languageEnglish
Pages (from-to)187-198
Number of pages12
JournalWiener Klinische Wochenschrift
Volume127
DOIs
Publication statusPublished - 1 Dec 2015
Externally publishedYes

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Keywords

  • Allograft
  • Autograft
  • Scaffold
  • Tissue engineering
  • Tissue-engineered skin

ASJC Scopus subject areas

  • Medicine(all)

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