A Review on 1,1-Bis(diphenylphosphino)methane bridged homo- and heterobimetallic complexes for anticancer applications: synthesis, structure, and cytotoxicity

Matylda Odachowski, Christoph Marschner, Burgert Blom

Research output: Contribution to journalReview article

Abstract

Herein, we review developments in synthesis, structure, and biological (anti-cancer) activities of 1,1-bis(diphenylphosphino)methane (dppm) bridged homo- and heterobimetallic systems of the type L mM(μ 2-dppm)M'L n (M and M′ are transition metals which may be different or the same and L n,m are co-ligands) since the first such reported bimetallic system in 1987 until the present time (2020). As the simplest diphosphine, dppm enables facile formation of bimetallic complexes, where, given the short spacer between the PPh 2 groups, close spatial proximity of the metal centres is ensured. We concentrate on complexes bearing no M–M interaction and contrast biological activities of these complexes with mononuclear counterparts and positive control agents such as cisplatin, in an attempt to elucidate patterns in the biological activities of these complexes.

Original languageEnglish
Article number112613
Number of pages62
JournalEuropean Journal of Medicinal Chemistry
Volume204
Issue number204
DOIs
Publication statusPublished - 15 Oct 2020

Keywords

  • Anti-cancer activity
  • Bimetallic complexes
  • Heterobimetallic complexes
  • Homobimetallic complexes

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Organic Chemistry

Fields of Expertise

  • Advanced Materials Science

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