Abstract
Herein, we review developments in synthesis, structure, and biological (anti-cancer) activities of 1,1-bis(diphenylphosphino)methane (dppm) bridged homo- and heterobimetallic systems of the type L mM(μ 2-dppm)M'L n (M and M′ are transition metals which may be different or the same and L n,m are co-ligands) since the first such reported bimetallic system in 1987 until the present time (2020). As the simplest diphosphine, dppm enables facile formation of bimetallic complexes, where, given the short spacer between the PPh 2 groups, close spatial proximity of the metal centres is ensured. We concentrate on complexes bearing no M–M interaction and contrast biological activities of these complexes with mononuclear counterparts and positive control agents such as cisplatin, in an attempt to elucidate patterns in the biological activities of these complexes.
Original language | English |
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Article number | 112613 |
Number of pages | 62 |
Journal | European Journal of Medicinal Chemistry |
Volume | 204 |
Issue number | 204 |
DOIs | |
Publication status | Published - 15 Oct 2020 |
Keywords
- Anti-cancer activity
- Bimetallic complexes
- Heterobimetallic complexes
- Homobimetallic complexes
ASJC Scopus subject areas
- Drug Discovery
- Pharmacology
- Organic Chemistry
Fields of Expertise
- Advanced Materials Science